DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and MX2

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_002454.1	Gene:	MX2 / 4600	HGNCID:	7533	Length:	715	Species:	Homo sapiens

Alignment Length:	750	Identity:	196/750 - (26%)
Similarity:	326/750 - (43%)	Gaps:	155/750 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIY 69
            |.|: |.|....:| ...:.||.|.|:|.||||||||:|::.|.: ||||:|||||.||||:|..
Human    99 PCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVLKLKK 161

  Fly    70 SPLDDRENRSAENGTSNAEEW-GR--FLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEPINL 131
            .|               .|.| ||  :.:|:....|..::.|||.......||:.:||..|.|:|
Human   162 QP---------------CEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISL 211

  Fly   132 KIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEAL 196
            :|.|..|.:||::||||||:|.|.:||.||..|||.|:.|||:...:|.|.|...|.|:||:|||
Human   212 EITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEAL 276

  Fly   197 KLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHIDD 259
            .:|.:|||:|.||:.::||.||||.||:  .::::.....|:|.|.:.|..|.|::|.::..:.:
Human   277 SMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAE 341

  Fly   260 QMKDEAAFLQ-RKYPTLATRNGT---PYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNS 320
            ..|.|..|.| ..|..:....|:   |.||:.|...|:.||:..||.|:.::.....:....|..
Human   342 ATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRR 406

  Fly   321 YGEDV----SDKSQTLLQIITKFSSAYCCTIEG--TARNIETTELCGGARMGYIFHETF----GR 375
            .|.|:    :||...|::.|..|:......:||  ..|..||       |:.....|.|    |.
Human   407 CGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENET-------RLYNKIREDFKNWVGI 464

  Fly   376 TLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQR 440
            ...:...:..:...::....:...|.....||...:||::|.:.|::|.||:|   .::.:.|:.
Human   465 LATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPAL---SMLQKAMEI 526

  Fly   441 IVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAA 505
            |.|...|..::....|..|::.:...:..:   ::.|| ...||::.::   ...:...|.:|..
Human   527 IQQAFINVAKKHFGEFFNLNQTVQSTIEDI---KVKHT-AKAENMIQLQ---FRMEQMVFCQDQI 584

  Fly   506 LVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQ 570
            ....|.|...:.::.:       .||..:|  :::||.           |...||...::::
Human   585 YSVVLKKVREEIFNPL-------GTPSQNM--KLNSHF-----------PSNESSVSSFTEI--- 626

  Fly   571 NHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRL 635
                                                 .:|.|
Human   627 -------------------------------------GIHLN----------------------- 631

  Fly   636 TDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLN 700
                            :||....|.:.:.:|..|.:|::....|:||..::..|.:.::...||.
Human   632 ----------------AYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQ 680

  Fly   701 ESDHIAVRRKEAADMLKALTRANHIISEI--RETH 733
            |....|.:|:...:.:..||:|.|.:.:.  :|.|
Human   681 EQSETATKRRILKERIYRLTQARHALCQFSSKEIH 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	115/286 (40%)
		CrfC	88..728	CDD:223771	159/658 (24%)
		Dynamin_M	226..507	CDD:279383	63/294 (21%)
		GED	643..729	CDD:280391	19/85 (22%)
MX2	NP_002454.1	nuclear localization signal (NLS)	1..24
		DLP_1	116..387	CDD:206738	115/286 (40%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	125..132		5/6 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	150..152		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	225..228		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	294..297		2/2 (100%)
		Dynamin_M	307..593	CDD:307257	65/302 (22%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	326..329		0/2 (0%)
		GED	621..709	CDD:128597	21/166 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910