Protein Alignment Drp1 and shi

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001259588.1
• Gene: shi / 45928
• FlyBaseID: FBgn0003392
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 816
• Identity: 296/816 - (36%)
• Similarity: 433/816 - (53%)
• Gaps: 148/816 - (18%)

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            |::||.::|||||.|.::|.. .:.||||.|:|.||:|||||:|:.||:.|||||:||||||||:
  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||             ||.:   |:|.|||.| |.|:.|||||||||:||:|..||||||...|
  Fly    66 LQLI-------------NGVT---EYGEFLHIKGKKFSSFDEIRKEIEDETDRVTGSNKGISNIP 114

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.||:||||:||||:|||.:||||.|||.|||:::.::|.....:|||||.||||:|.|
  Fly   115 INLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANS 179

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||:|||.|.||:.|:|||||||.||||.|||..:::|::.|.|||:|||||||..:|.|.
  Fly   180 DALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIEGRKDIH 244

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.  ...|..:|.|.|||||.:.||:.|.:||||.||.|:.::.......:..:..:
  Fly   245 QALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQKQMLTLEKEVEEF 309

  Fly   322 GE----DVSDKSQTLLQIITKFSSAYCCTIEGT-ARNIETTELCGGARMGYIFHETFGRTLDSIH 381
            ..    |.|.|::.:||:|.:..|.:..||||: :..:.|.||.|||::..||||   |....|.
  Fly   310 KHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHE---RLRFEIV 371

  Fly   382 PLAGLSK---MDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQ 443
            .:|...|   .:|..||||..|.|..||.|:::||.:|||||..|:||.::||:|:.:|:..:|:
  Fly   372 KMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQELSVVVR 436

  Fly   444 HCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF-------- 500
            .|    ..:|.|:|:|.|:...::|..:|:|.......:..::..||||:||.|.||
  Fly   437 MC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTNHEDFIGFANAQN 497

  Fly   501 ------------------HKDAALVPSL--LKTDSDPYSQINLGQRRANTPRN--HMSPQ----- 538
                              .|...::.:|  :|       .|.||:   :.|.|  ..||.
  Fly   498 KSENANKTGTRQLGNQVIRKGHMVIQNLGIMK-------DIKLGR---SGPLNVRFFSPSTGGSR 552

  Fly   539 -----ISSHSAGSQQPQQQQ--------------------------------PPQPNSSQQQYSQ 566
                 ::|.|....:.:.::                                .|...:..:.|.|
  Fly   553 PYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKDYKQ 617

  Fly   567 VHEQNHVAENSTPSMASTWLSNILPPA--PTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPAN 629
            :.......|:     ..:|.::.|...  |.:.::.||...:....::
  Fly   618 LELSCETVED-----VESWKASFLRAGVYPEKQETQENGDESASEESS----------------- 660

  Fly   630 HNPRRLTDKE-QKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSD 693
                  :|.: ::..:.|.:|:.||..||.|:.:|.||||||..::|..||.:..||:.|||.|.
  Fly   661 ------SDPQLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASG 719

  Fly   694 KAETLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            ....::.||...|.||:|...|.:|...|..||.::
  Fly   720 DQAQMMEESAESATRREEMLRMYRACKDALQIIGDV 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	159/280 (57%)
		Dynamin_M	224..507	CDD:460033	108/318 (34%)
		GED	639..729	CDD:460495	34/90 (38%)
shi	NP_001259588.1	DYNc	1..240	CDD:197491	150/254 (59%)
		Dynamin_M	210..498	CDD:460033	107/294 (36%)
		PH_dynamin	512..644	CDD:269958	19/146 (13%)
		GED	664..755	CDD:128597	34/90 (38%)
		FAP	725..>855	CDD:429334	11/31 (35%)