DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and dnm1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_031746176.1	Gene:	dnm1 / 448130	XenbaseID:	XB-GENE-986845	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	818	Identity:	295/818 - (36%)
Similarity:	444/818 - (54%)	Gaps:	142/818 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:::|.: ::.||||.|:|.||:|||||:|:.||:.|||||:|||||||||
Frog     6 MEELIPLVNRLQDAFSSIGQNANLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            |||:                :::.|:|.|||.| |.||||||||.|||.||:||.|:||||.|.|
Frog    71 LQLV----------------NSSTEYGEFLHCKGKKFTDFDEIRLEIEAETDRATGTNKGISPVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.:|:|||||||||:|||||||||.|||.||::::::::...|.::|||:.||:|:|.|
Frog   120 INLRVYSPNVLNLTLVDLPGMTKVPVGDQPVDIEFQIRDMLMQFVTKENCLVLAVSPANSDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|.||:.|:|||||||.||||.|:|..:::|::.|.|||:|||||||..:|.|.
Frog   185 DALKIAKEVDPKGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDIQ 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.  ...|..||.|.|||||.|.||:.|.:||||.||.|:.::.......:..:..|
Frog   250 AALAAERKFFLSHPSYRHLADRMGTPYLQKALNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.:.|::.||.::.:|:..:...|||:...|:|.||.||||:..||||.|...|..:..
Frog   315 KNFRPDDPARKTKALLLMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:||::::||.|:||:::..|:...|:.|..
Frog   380 DEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQIKKIKEPCLKCVDMVISELIGTVRQCTK 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF------------ 500
            ::.|    :|.|.|::..:||..:|.|...|...|..::.|||:|:||.|.||
Frog   445 KLSQ----YPHLREEMERIVTTHIREREGRTKDQVMLLIDIELSYMNTNHEDFIGFANAQQRSSQ 505

  Fly   501 --------HKDAALV----------PSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQ 547
                    ::|..||          ..::|..|..|..:...:            .:|.:....:
Frog   506 TNKKKASGNQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAE------------NLSWYKDDEE 558

  Fly   548 QPQQQQPPQPN-------SSQQQY-----------------SQVH-------EQNHVAEN----- 576
            ..::...|..|       ..:::|                 |..|       ||.:|.::
Frog   559 MEKKYMLPVDNLKLRDIKEKEKKYMLPLDNLKLRDIEKGFMSSKHIFALFNTEQRNVYKDYRQLE 623

  Fly   577 ---STPSMASTWLSNILPPA--PTR-------PDSIENSTNNTPVHNNIVSPVKPVNLLPDVPAN 629
               .|.....:|.::.|...  |.|       .:|.||.:::. :|:
Frog   624 LACETQEEVDSWKASFLRAGVYPERAGDKDKASESEENGSDSF-MHS------------------ 669

  Fly   630 HNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDK 694
                 :..:.::..:.|.:|:.||..||.|:|:|.:||.|||.::...||.:.|:|:.:||....
Frog   670 -----MDPQLERQVETIRNLVDSYMAIVNKTIRDLMPKTIMHLMIINTKDFIHSDLLANLYSCGD 729

  Fly   695 AETLLNESDHIAVRRKEAADMLKALTRANHIISEIRET 732
            ..||:.||...|..|.|...|.:||..|..||.:|..|
Frog   730 QNTLMEESAEQAQHRDEMLKMYRALKEALCIIGDISTT 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	157/280 (56%)
		CrfC	88..728	CDD:223771	249/724 (34%)
		Dynamin_M	226..507	CDD:279383	104/306 (34%)
		GED	643..729	CDD:280391	33/85 (39%)
dnm1	XP_031746176.1	DYNc	6..245	CDD:197491	147/254 (58%)
		Dynamin_M	216..502	CDD:395818	104/289 (36%)
		PH_dynamin	520..648	CDD:269958	17/139 (12%)
		GED	676..764	CDD:396682	33/87 (38%)
		PHA03378	<771..872	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010