DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and dnm1l

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_005163105.1	Gene:	dnm1l / 393896	ZFINID:	ZDB-GENE-040426-1556	Length:	727	Species:	Danio rerio

Alignment Length:	764	Identity:	486/764 - (63%)
Similarity:	576/764 - (75%)	Gaps:	66/764 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |||||||||||||||||||:|.||||||.|:|:||||||||:||:|||..|||||||||||||:|
Zfish     1 MEALIPVINKLQDVFNTVGADIIQLPQIAVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLIL 65

  Fly    66 QLIYSPLDDRENRSAENGTS-----------NAEEWGRFLHTK-KCFTDFDEIRKEIENETERAA 118
            ||::...:||...|.||..:           :.||||:||||| |.:|||||||:||||||||.:
Zfish    66 QLVHVDPEDRRKTSEENEPNTWKNGRLYKGVDGEEWGKFLHTKNKIYTDFDEIRQEIENETERVS 130

  Fly   119 GSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAV 183
            |:||||..|||:|||||.||||||||||||||||||||||:|||.||:||:||||.|||||||||
Zfish   131 GNNKGISDEPIHLKIFSPHVVNLTLVDLPGITKVPVGDQPKDIELQIRELILKYISNPNSIILAV 195

  Fly   184 TAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQ 248
            ||||||||||||||:|::||||||||||||||||||||||||:|:|.|||||||||:|||:||||
Zfish   196 TAANTDMATSEALKVAREVDPDGRRTLAVVTKLDLMDAGTDAMDVLMGRVIPVKLGLIGVVNRSQ 260

  Fly   249 KDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQ 313
            .||.::|.:.|.::||..|||:|||:||.||||.|||:|||||||||||||||:||||:|:::.|
Zfish   261 LDINNKKSVADSIRDEHGFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLSAQ 325

  Fly   314 FQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLD 378
            :||||:||||.|.|.|.||||:||||::.||.||||||:.|||.|||||||:.|||||||||||:
Zfish   326 YQSLLSSYGEPVEDMSATLLQLITKFATEYCNTIEGTAKYIETAELCGGARICYIFHETFGRTLE 390

  Fly   379 SIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQ 443
            |:.||.||:.:|:||||||||||||||||||||||||||||::||||||||||||:|||||||:|
Zfish   391 SVDPLGGLTTIDVLTAIRNATGPRPALFVPEVSFELLVKRQVKRLEEPSLRCVELVHEEMQRIIQ 455

  Fly   444 HCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVP 508
            ||.|...||:|||||||:.||:|||.|||:|||.||.||.|:|||||||||||||||.....|:.
Zfish   456 HCSNYSTQELLRFPKLHDAIVEVVTSLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMN 520

  Fly   509 SLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQP-PQPNSSQQQYSQVHEQNH 572
            :            |:.::|.|..|...:......|......|...| .||:
Zfish   521 N------------NIEEQRRNRMRELPTSVPRDKSLKGPGGQSMSPTDQPS-------------- 559

  Fly   573 VAENSTPSMA-----------STWLSNILPPAPTRPDSIENSTNNTPVHNNI-VSPVK--PVNLL 623
             ||...|.||           .||...:      :..........|.:.::| .||.|  .||||
Zfish   560 -AEGDGPKMAGGAQAEQEGGTGTWRGML------KKGDEGQGEEKTKLQSSIPASPQKGHAVNLL 617

  Fly   624 PDVPANHNP--RRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELV 686
             |||.   |  |:|:.:||:||:|||.||||||.||||:||||||||:||||||:|||:||||||
Zfish   618 -DVPV---PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDSLQSELV 678

  Fly   687 THLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRETHMW 735
            ..|||....:.||.||:.:|.||.|||||||||.:|:.:|:||||||:|
Zfish   679 GQLYKPALLDDLLTESEDMAQRRNEAADMLKALQKASQVIAEIRETHLW 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	213/289 (74%)
		CrfC	88..728	CDD:223771	417/657 (63%)
		Dynamin_M	226..507	CDD:279383	205/280 (73%)
		GED	643..729	CDD:280391	58/85 (68%)
dnm1l	XP_005163105.1	DLP_1	23..313	CDD:206738	213/289 (74%)
		CrfC	99..720	CDD:223771	417/657 (63%)
		Dynamin_M	238..521	CDD:279383	206/282 (73%)
		GED	633..721	CDD:280391	59/87 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	430	1.000	Domainoid score	I573
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	900	1.000	Inparanoid score	I365
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		otm25670
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870