DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and mxd

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_695562.6	Gene:	mxd / 360146	ZFINID:	ZDB-GENE-030721-8	Length:	644	Species:	Danio rerio

Alignment Length:	769	Identity:	194/769 - (25%)
Similarity:	311/769 - (40%)	Gaps:	211/769 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |.:.|.|: |.|...:|| .:.:.||.|||:|.||||||||:|::.|.: ||||:|||||.||.|
Zfish    41 ENIRPYID-LIDTLRSVGVQNEVSLPTIVVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLEL 103

  Fly    66 Q------------LIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIENETERAA 118
            :            |.|..:..|.::...|           |.|.: |.|...:.|.:.:.....|
Zfish   104 RLRKVTGVKWKAVLTYRSVKSRPDKQGNN-----------LKTFE-FEDSSIVEKHVTDAQNELA 156

  Fly   119 GSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAV 183
            |...|||.:.|.|::.|..|.:|||:|||||.:|||..||||:..|||.|::|||....:|.|.|
Zfish   157 GKGVGICDDLITLEVMSKDVCDLTLIDLPGIVRVPVAGQPEDVGDQIKRLIMKYIMKRETINLVV 221

  Fly   184 TAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNR 246
            ...|.|:||:|||::|::|||:|.||:|::||.||:|.||:  .:.::..:||.::.|...|..|
Zfish   222 VPCNIDIATTEALRMAQNVDPEGIRTVAILTKPDLIDKGTEKGILKVVQNKVIHLRKGYTMVKCR 286

  Fly   247 SQKDIMDQKHIDDQMKDEAAFLQR--KYPTLATRNGTPY--LAKTLNRLLMHHIRDCLPDLKTRV 307
            .|:.|.|:..:::.:::|..|.|.  .:..|.:.|....  ||..|.:.|:.||::.|..:..:|
Zfish   287 GQQQINDRITLEEALEEEKEFFQNHDTFRCLLSENKATIKCLAVKLTKDLVDHIKNSLQRVDDQV 351

  Fly   308 NIMATQFQSLLNSY----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIET--TELCGGAR-- 364
            ..:....::.|...    .:|.....|.|::.|.||:........|.....|.  .||.|..:
Zfish   352 KKLLWDVKNELKECEGGPPQDPKGAKQFLIKTIKKFNDIVTSMSSGELMLNENLFAELRGEFKKW 416

  Fly   365 ----------MGY---IFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLV 416
                      ..|   :..:..||.|.      |.|...:                    ||.::
Zfish   417 NDHLEQKKSPFNYSKELMKKNRGRELH------GFSNYKL--------------------FETIL 455

  Fly   417 KRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVM 481
            :..:.:|:||:   :.|:|:....|.:|..:.|.|....:|.|....:.               .
Zfish   456 QDHVAQLKEPA---INLLHKANGIIAKHLTDRVSQCFRNYPALQSIAMG---------------K 502

  Fly   482 VENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGS 546
            .|||
Zfish   503 AENI------------------------------------------------------------- 506

  Fly   547 QQPQQQQPPQPNSSQQQY---SQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTP 608
                        .|:|||   .::.||..: ||...:..|.:|..:
Zfish   507 ------------QSRQQYKTEQRISEQFDM-ENIIYTQDSVFLKTL------------------- 539

  Fly   609 VHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFL 673
              |.|.:.......||          |.||..|    ..|::::|:.||.:.:.|.:|..|:||:
Zfish   540 --NEITNERYSEEELP----------LIDKACK----YSHMLETYYEIVAQRLTDQLPLMIIHFM 588

  Fly   674 VNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIIS 727
            :....:.:..|::: |........||.|...::.:|.|....||.||.|...::
Zfish   589 LKQTAEIMSIEMLS-LVDGTNVSKLLFEDTEVSRKRTELRARLKRLTDAQEALN 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	112/295 (38%)
		CrfC	88..728	CDD:223771	155/670 (23%)
		Dynamin_M	226..507	CDD:279383	55/305 (18%)
		GED	643..729	CDD:280391	21/85 (25%)
mxd	XP_695562.6	DLP_1	62..344	CDD:206738	112/294 (38%)
		Dynamin_M	266..544	CDD:279383	67/416 (16%)
		GED	564..643	CDD:280391	20/79 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910