Protein Alignment Drp1 and mxc

DIOPT Version :9

• Sequence 1: NP_001259946.1
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001007285.1
• Gene: mxc / 360145
• ZFINID: ZDB-GENE-030721-7
• Length: 626
• Species: Danio rerio
• Alignment Length: 763
• Identity: 194/763 - (25%)
• Similarity: 315/763 - (41%)
• Gaps: 193/763 - (25%)

  Fly     6 PVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIY 69
            |:|: |.|....:|.: .:.||.|.|:|.||||||||:|::.|.: ||||.|||||.||:|:|
Zfish    24 PIID-LVDTLRALGVEKDLNLPAIAVIGDQSSGKSSVLEALSGVA-LPRGIGIVTRCPLILKL-- 84

  Fly    70 SPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKE---IENETERA----AGSNKGICPE 127
                        ...:..:.|...|    .:.|..||.||   |||...:|    ||:.:||..|
Zfish    85 ------------KKITRDKNWSGLL----TYKDQTEILKEPTGIENAVLKAQIALAGTGEGISHE 133

  Fly   128 PINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMAT 192
            .|.|:|.|..|.:|||:|||||.:|..|:||||||.|||:|:.|:|:...:|.|.|..||.|:||
Zfish   134 MITLEIQSCDVPDLTLIDLPGIARVATGNQPEDIEKQIKDLIEKFIKRQETISLVVVPANIDIAT 198

  Fly   193 SEALKLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNRSQKDIMDQK 255
            :||||:|..|||.|:|||.::||.||:|.|.:  .:..:...||.::.|.:.|..|.|:||.|:.
Zfish   199 TEALKMASTVDPTGQRTLCILTKPDLVDRGMEDTVVRTVNNEVIRLEKGYMIVKCRGQQDINDKL 263

  Fly   256 HIDDQMKDEAAFLQRKYPTLAT-----RNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQ 315
            ::.:.::.|..|.. ::|..::     :...|.|.:.|...|:.||...:|.|:.::.:...:..
Zfish   264 NLVEALEKERRFFD-EHPQFSSLLEDGKATIPLLGQRLTEELVEHIAKNVPRLQNQIEMKLQKTF 327

  Fly   316 SLLNSYGEDVSDKSQT-----LLQIITKFSSAYCCTIEGTARNIE-----TTELCGGARMGYIFH 370
            ..|...||.|.|..:.     |::.:.:|..|    :|...|..|     .|.:....|..::
Zfish   328 ERLKVLGESVPDDDEIELNNFLIKKLRQFMDA----LEEVKRVEEEPVKSDTRVFSKIRQEFV-- 386

  Fly   371 ETFGRTLDSIHPLAGLSKM--DILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCV-- 431
             ::...||| .|:    ||  |:...:|...|.....|:...:|..:::..:..||||:|:.:
Zfish   387 -SWKHILDS-KPI----KMSTDLQEYVRTHRGKELPGFLNYGTFAGIIRMHVEDLEEPALKLLRN 445

  Fly   432 --ELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYIN 494
              :::|..:..|..                                .|.|.....::|::.....
Zfish   446 AKDIVHSSVGSIAN--------------------------------IHFNGYPNLLLAVKEPIEK 478

  Fly   495 TKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNS 559
            ..|..|......:.|..|.:...|.|.:|
Zfish   479 CLHEQFQNAEEKIRSQFKLEKTVYCQDDL------------------------------------ 507

  Fly   560 SQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLP 624
                |:     ||:              |:|.|..|....:|.|..|:.:...
Zfish   508 ----YT-----NHL--------------NLLRPKNTVRFGLEASLGNSELRET------------ 537

  Fly   625 DVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHL 689
               |.|                   :.||..|..:.:.:.:|..:.:.::|.....||:.::..:
Zfish   538 ---AFH-------------------LTSYLTIACERLANQIPLIVQYHMMNEYNSQLQNAMLGLI 580

  Fly   690 YKSDKAETLLNESDHIAVRR--KEAADMLKALTRANHIISEIRETHMW 735
            ..||....|..:|....:|:  ||..:.||...||  :...:...:.|
Zfish   581 GTSDPGMLLCEDSGVARIRKDLKERLERLKDARRA--LPKVVHSANSW 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	115/291 (40%)
		CrfC	88..728	CDD:223771	160/671 (24%)
		Dynamin_M	226..507	CDD:279383	56/301 (19%)
		GED	643..729	CDD:280391	18/87 (21%)
mxc	NP_001007285.1	DLP_1	41..313	CDD:206738	115/291 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	50..57		5/6 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	75..77		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	151..154		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	220..223		2/2 (100%)
		Dynamin_M	234..516	CDD:279383	65/385 (17%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	252..255		0/2 (0%)
		GED	532..619	CDD:280391	20/122 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910