Protein Alignment Drp1 and mxa

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_891987.2
• Gene: mxa / 360142
• ZFINID: ZDB-GENE-030721-5
• Length: 632
• Species: Danio rerio
• Alignment Length: 772
• Identity: 206/772 - (26%)
• Similarity: 321/772 - (41%)
• Gaps: 203/772 - (26%)

  Fly     2 EALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQ 66
            |.:.|.|:.:.::.:......:.||.|.|:|.||||||||:|::.|.. ||||:|||||.||.|:
Zfish    14 EKIRPCIDTIDNLRSLGVEKDLALPAIAVIGDQSSGKSSVLEALSGVP-LPRGSGIVTRCPLELK 77

  Fly    67 LIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFD---EIRKEIENETERAAGSNKGICPEP 128
            :|              .|.:.::|...:..|....|||   |:.|:|....:..||:..||..|.
Zfish    78 MI--------------RTKDQDKWHGRISYKTYEEDFDDPAEVEKKIRQAQDEMAGAGVGISEEL 128

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |:|:|.|.:|.:|||:|||||.:|.|..|||:|..|||.|:.|::....:|.|.|...|.|:||:
Zfish   129 ISLQITSANVPDLTLIDLPGIARVAVKGQPENIGDQIKRLIRKFVTRQETINLVVVPCNVDIATT 193

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNRSQKDIMDQKH 256
            |||::|:..||||.|||.::||.||:|.||:  .:||:...||.:..|.:.|..|.||:||||..
Zfish   194 EALQMAQAEDPDGERTLGILTKPDLVDKGTEGTVVDIVHNEVIHLTKGYMIVRCRGQKEIMDQVT 258

  Fly   257 IDDQMKDEAAFL----------QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMA 311
            :::..:.|:||.          :..:.|:      |.||:.|...|:|||:..||.|:.::....
Zfish   259 LNEATETESAFFKDHPHFSKLYEEGFATI------PKLAEKLTIELVHHIQKSLPRLEEQIETKL 317

  Fly   312 TQFQSLLNSYGE-DVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGA------------ 363
            .:.|..|.:||. ..|:.:..|...|.|.          ||.|.:...|..|.
Zfish   318 AETQKELEAYGNGPPSEPAARLSFFIDKV----------TAFNQDMLNLTTGEDVKCTTDLLLFP 372

  Fly   364 --------------RMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFEL 414
                          |.|..|::...:.:|:         .::....|...|     |:...:||.
Zfish   373 ELRQEFAKWSHILDRSGDSFNKKIEKEVDN---------YEVKYRGRELPG-----FINYKTFEG 423

  Fly   415 LVKRQIRRLEEPSLRCVELIHEEM-QRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHT 478
            ||:.||:.||||:|:.::.:.:.: ::.:|    ..|...:.||.|               |...
Zfish   424 LVRDQIKLLEEPALKTLKTVSDVVRKKFIQ----LAQCSFIGFPNL---------------LKIA 469

  Fly   479 NVMVENIVAIELAYINTKHPDFHKDAALVPSLLKT----DSDPYSQINLGQRRANTPRNHMSPQI 539
            ...:|.|             ..:|: :|..|:|||    :...|||            :....|.
Zfish   470 KTKIEGI-------------KLNKE-SLAESMLKTQFKMELIVYSQ------------DGTYSQS 508

  Fly   540 SSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENST 604
            ..|:....:..:::.|||.......|                                 |.:..|
Zfish   509 LKHAKDKLEEMEKERPQPKIKLPLLS---------------------------------SFDLGT 540

  Fly   605 NNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAI 669
            :|   |                 |.....||            || |||:.|..|.:.|.:|..|
Zfish   541 DN---H-----------------ATLREMRL------------HL-KSYYTIASKRLADQIPMVI 572

  Fly   670 MHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHII 726
            .:.|:......||..::..|...|..:.||.|...|..:|:......|.|.:|..::
Zfish   573 RYMLLQEAALELQRNMLQLLQDKDGVDNLLKEDCDIGQKRENLLSRQKRLMKARSLL 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	116/292 (40%)
		Dynamin_M	224..507	CDD:460033	68/322 (21%)
		GED	639..729	CDD:460495	23/88 (26%)
mxa	NP_891987.2	DLP_1	35..307	CDD:206738	116/292 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	44..51		5/6 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	69..71		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	145..148		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	214..217		2/2 (100%)
		Dynamin_M	226..510	CDD:460033	77/358 (22%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	246..249		0/2 (0%)
		GED	542..632	CDD:460495	28/121 (23%)