Protein Alignment Drp1 and Mx2

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_599177.2
• Gene: Mx2 / 286918
• RGDID: 628821
• Length: 659
• Species: Rattus norvegicus
• Alignment Length: 758
• Identity: 195/758 - (25%)
• Similarity: 314/758 - (41%)
• Gaps: 177/758 - (23%)

  Fly     2 EALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |.:.|.|: |.|....:| ...:.||.|.|:|.||||||||:|::.|.: ||||:|||||.||||
  Rat    45 EKVRPCID-LIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVL 107

  Fly    66 QLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIE--NETERA--------AGS 120
            :|              ...:..|||       |....:|:|..|:.  :|.|.|        ||.
  Rat   108 KL--------------KKLNQGEEW-------KGKVTYDDIEVELSDPSEVEEAINTGQNHIAGV 151

  Fly   121 NKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTA 185
            ..||..:.|:|.:.|.||.:|||:||||||:|.||:||.||..|||.|:..||:...:|.|.|..
  Rat   152 GLGISDKLISLDVSSPHVPDLTLIDLPGITRVAVGNQPADIGRQIKRLITNYIQKQETINLVVVP 216

  Fly   186 ANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNRSQ 248
            :|.|:||:|||.:|:.|||||.||:.::||.||:|.||:  .:|::...|..:|.|.:.|..|.|
  Rat   217 SNVDIATTEALSMAQKVDPDGDRTIGILTKPDLVDRGTEDKVVDVVRNLVCHLKKGYMIVKCRGQ 281

  Fly   249 KDIMDQKHIDDQMKDEAAFLQRKYPTLAT-----RNGTPYLAKTLNRLLMHHIRDCLPDLKTRVN 308
            :||.:|..:.:.::.|..|. :::|....     :...|.||:.|...|:.||...||.|:.::.
  Rat   282 QDIQEQLSLAEALQKEQVFF-KEHPQFRALLEDGKATVPCLAERLTMELISHICKSLPLLENQIK 345

  Fly   309 IMATQFQSLLNSYG----EDVSDKSQTLLQIITKFSSAYCCTIEG--TARNIETTELCGGARMGY 367
            .........|..||    ||.::|:..|::.|..|:......:||  ..|..|........:..:
  Rat   346 ESHQSTSEELQKYGADIPEDENEKTLFLIEKINAFNQDITAIVEGEEIVREKECRLFTKLRKEFF 410

  Fly   368 IFHE----TFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSL 428
            ::.|    .|.:..|:::       .::.|......|.....||...:||.:::|||:.||||::
  Rat   411 LWSEEIERNFQKGSDALY-------KEVYTFEMQYRGRELPGFVNYKTFENIIRRQIKTLEEPAM 468

  Fly   429 RCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYI 493
               |::|                          |:.::|      |...|.|..:|.
  Rat   469 ---EMLH--------------------------KVTEIV------RAAFTTVSEKNF-------- 490

  Fly   494 NTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPN 558
                .:|.       :|.:|.......|.|.|      .......|..|....|....|......
  Rat   491 ----SEFF-------NLHRTTKSKLEDIRLEQ------ETEAEKAIRLHFQMEQIIYCQDQIYRK 538

  Fly   559 SSQ---QQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPV 620
            :.|   ::.::..|:.|....|..|                 .:::.|:.:
  Rat   539 ALQKVREEEAEEEERKHGKSRSAQS-----------------PNLQTSSMD-------------- 572

  Fly   621 NLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSEL 685
                                   ::.:|| .:|.......|...:|..|.:|::....:.||..:
  Rat   573 -----------------------EIFQHL-NAYRQEAHNCISSHIPLIIQYFILKMFAEKLQKGM 613

  Fly   686 VTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISE 728
            :..|...|....||.|....:.:|:...:.|..|.:|...:::
  Rat   614 LQLLQDKDSCSWLLKEKSDTSEKRRFLKERLARLAQAQRRLAK 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	115/294 (39%)
		Dynamin_M	224..507	CDD:460033	61/299 (20%)
		GED	639..729	CDD:460495	18/90 (20%)
Mx2	NP_599177.2	DLP_1	66..338	CDD:206738	115/294 (39%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	75..82		5/6 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	100..102		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	176..179		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	245..248		2/2 (100%)
		Dynamin_M	257..544	CDD:460033	71/354 (20%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	277..280		0/2 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	547..568		4/37 (11%)
		GED	567..657	CDD:460495	19/128 (15%)