DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DNM3

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_016856465.1	Gene:	DNM3 / 26052	HGNCID:	29125	Length:	921	Species:	Homo sapiens

Alignment Length:	829	Identity:	311/829 - (37%)
Similarity:	443/829 - (53%)	Gaps:	137/829 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:.:| |..::||||.|:|.||:|||||:|:.|||.|||||:|||||||||
Human     6 MEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            |||:               ||.| |:..|||.| |.||||||:|.|||.||:|..|.||||...|
Human    71 LQLV---------------TSKA-EYAEFLHCKGKKFTDFDEVRLEIEAETDRVTGMNKGISSIP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.||:||||:||||||||||||||.|||.||:|:::::|...|.:|||||.||||:|.|
Human   120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||:|||.|.||:.|:|||||||.||||.|:|..:::|::.|.:||:|||||||..:|.|.
Human   185 DALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIK 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..|..|..|.  ...|..:|.|.|||:|.|.||:.|.:||||.||:.:.::.......:..:.:|
Human   250 AAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .||.:.|::.|||::.:|:..:...|||:...::|.||.|||::..||||.|...:..:..
Human   315 KNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:||.:|:.|||:.|:|:.:|:...|:.|
Human   380 NEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVIQELINTVKKC-- 442

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF------------ 500
              .:::..||:|.|:...:|...:|.|...|...|..::.|:::||||.|.||
Human   443 --TKKLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFANAQQRSSQ 505

  Fly   501 -HKDAA-------LVPS----------------LLKTDSDPY------------------SQI-- 521
             ||...       |.||                ::|..|..|                  ||.
Human   506 VHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSKGYWFVLTAESLSWYKDDEIPSQTGL 570

  Fly   522 --NLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPP--QPNSSQQQY-----------------S 565
              :|.|.....|....|.|.......|...|:..|.  |....:::|                 |
Human   571 LPDLQQGFPLLPHEIYSNQRCKEHLNSYFLQEVFPDHLQLKEKEKKYMLPLDNLKVRDVEKSFMS 635

  Fly   566 QVH-------EQNHVAEN--------STPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVS 615
            ..|       ||.:|.::        .:.....:|.:::| .|...||   .|..|....|:...
Human   636 SKHIFALFNTEQRNVYKDYRFLELACDSQEDVDSWKASLL-RAGVYPD---KSVGNNKAENDENG 696

  Fly   616 PVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDN 680
            ..:..::.|.:             ::..:.|.:|:.||..|:.|.|:|.:||.|||.::|.|||.
Human   697 QAENFSMDPQL-------------ERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDF 748

  Fly   681 LQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEI 729
            :.|||:..||.|:...||:.||...|.||.|...|.:||..|..||.:|
Human   749 INSELLAQLYSSEDQNTLMEESAEQAQRRDEMLRMYQALKEALGIIGDI 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	162/280 (58%)
		CrfC	88..728	CDD:223771	261/738 (35%)
		Dynamin_M	226..507	CDD:279383	100/306 (33%)
		GED	643..729	CDD:280391	37/85 (44%)
DNM3	XP_016856465.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720