Protein Alignment Drp1 and vps1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001342849.1
• Gene: vps1 / 2542724
• PomBaseID: SPAC767.01C
• Length: 678
• Species: Schizosaccharomyces pombe
• Alignment Length: 746
• Identity: 312/746 - (41%)
• Similarity: 442/746 - (59%)
• Gaps: 90/746 - (12%)

  Fly     3 ALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQ 66
            :||.|:|:||:.|:||| .:.|.||||.|:.|||||||||:|::|||.|||||||||||||||||
pombe     4 SLIKVVNQLQEAFSTVGVQNLIDLPQITVVRSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQ 68

  Fly    67 LIYSPLDDRENRSAENGT-----SNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGIC 125
            ||..|....:|......:     :|:.|||.|||.. :.|.:|::||:||..|||...|.|.||.
pombe    69 LINRPSASGKNEETTTDSDGKDQNNSSEWGEFLHLPGQKFFEFEKIREEIVRETEEKTGKNVGIS 133

  Fly   126 PEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDM 190
            ..||.|:|:|.||:.||||||||:|||||||||.|||.||:|:|||||...|:|||||.|||||:
pombe   134 SVPIYLRIYSPHVLTLTLVDLPGLTKVPVGDQPRDIEKQIREMVLKYISKNNAIILAVNAANTDL 198

  Fly   191 ATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQK 255
            |.|:.||||::|||:|.||:.|:||:||||.|||.:|||.|||||::||.:.|:||.||||..:|
pombe   199 ANSDGLKLAREVDPEGLRTIGVLTKVDLMDKGTDVVDILAGRVIPLRLGYVPVINRGQKDIEGKK 263

  Fly   256 HIDDQMKDEAAFLQR--KYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLL 318
            .|...::.|..|.:.  .|.:.|...|||:||:.||.:||||||:.||::|.|:|....::|:.|
pombe   264 SIRIALEAERNFFETHPSYGSKAQYCGTPFLARKLNMILMHHIRNTLPEIKVRINAALAKYQAEL 328

  Fly   319 NSYGE-DVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
            :|.|: .|.|.|..:|.:||.|.:.|...::|.:..:..|||.||||:.::|||.|...:.:|.|
pombe   329 HSLGDTPVGDNSSIVLNLITDFCNEYRTVVDGRSEELSATELSGGARIAFVFHEIFSNGIQAIDP 393

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            ...:...||.|.:.|::||.|:||:...:||::||:||:|||:|||:||.||::|:.||:    |
pombe   394 FDEVKDSDIRTILYNSSGPSPSLFMGTAAFEVIVKQQIKRLEDPSLKCVSLIYDELVRIL----N 454

  Fly   448 EVQQEML--RFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSL 510
            ::.|..:  |:|.|.::...||....|:.:..||.:|.::||:|.:||||.||||
pombe   455 QLLQRPIFKRYPLLKDEFYKVVIGFFRKCMQPTNTLVMDMVAMEGSYINTVHPDF---------- 509

  Fly   511 LKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAE 575
                                        :|.|.|.:....|...|.|
pombe   510 ----------------------------LSGHQAMAIVQSQNSKPIP------------------ 528

  Fly   576 NSTPSMASTWLSNILPPAPTRPDSIEN-------STNNTPVHNNIVSPVKPVNLLPDVPANHNPR 633
             ..|.......:|.:||..|...|.:|       |.|..          :...:.|..|......
pombe   529 -VDPKTGKALTNNPVPPVETSSSSGQNFFGSFFGSKNKK----------RLAAMEPPPPVLRAST 582

  Fly   634 RLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETL 698
            .|:|:|:.|.:||:.||.|||.||::::.|.|||:|...::.|.|:::|.||:..||||...:.|
pombe   583 TLSDREKTDTEVIKLLIMSYFNIVKRTLADMVPKSISLKMIKYSKEHIQHELLEQLYKSQAFDKL 647

  Fly   699 LNESDHIAVRRKEAADMLKALTRANHIISEI 729
            |.||:....||||...|:::|.:|:.|:|.:
pombe   648 LQESEVTVQRRKECEQMVESLLQASEIVSNV 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	164/285 (58%)
		Dynamin_M	224..507	CDD:460033	118/287 (41%)
		GED	639..729	CDD:460495	38/89 (43%)
vps1	NP_001342849.1	DLP_1	25..311	CDD:206738	164/285 (58%)
		Dynamin_M	232..517	CDD:460033	121/326 (37%)
		GED	588..678	CDD:460495	38/89 (43%)