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Protein Alignment Drp1 and Mfn1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_620432.1	Gene:	Mfn1 / 192647	RGDID:	621460	Length:	741	Species:	Rattus norvegicus

Alignment Length:	809	Identity:	135/809 - (16%)
Similarity:	247/809 - (30%)	Gaps:	299/809 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91
            ::...|..||||||||.:::....||.|.|
  Rat    77 KVAFFGRTSSGKSSVINAMLWDKVLPSGIG----------------------------------- 106

  Fly    92 RFLHTKKCF-----TDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITK 151
               ||..||     ||.|:.....|...|:     |.:  :.:|....:.|
  Rat   107 ---HTTNCFLSVEGTDGDKAYLMTEGSDEK-----KSV--KTVNQLAHALH-------------- 147

  Fly   152 VPVGDQPEDIEAQIKELVLKYIENPNS-------IILAVTAANTDMATSEALKLAKDVDPDGRRT 209
                     ::..:|...|.::..|.:       .::.|.:..||
  Rat   148 ---------MDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTD-------------------- 183

  Fly   210 LAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMD-QKH----IDDQM-KDEAAFL 268
              |.|:||:.      ||..|     :...:..::..|:..:|: :||    ::::: |.....|
  Rat   184 --VTTELDIW------IDKFC-----LDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFIL 235

  Fly   269 QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCL----------PDLKTRVNIMATQFQSLLNSY-- 321
            ..::...|:.   |...:.:.|   .|:..||          ..|:.|..|.....:.:|||.
  Rat   236 NNRWDASASE---PEYMEDVRR---QHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMN 294

  Fly   322 --------GEDVSDKSQTLLQIITKFSSAY--CCT-----------------IEGTARNI-ETTE 358
                    |..:::..|..||....|...:  |.:                 |..|.:|| ::..
  Rat   295 KAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVN 359

  Fly   359 LCGGARMGYIFHETFGR--TLDSIHPLAGLSKMDILTAIRNATGP--------------RPALFV 407
            :....:..|...|...:  .||.|.....|..||:...|:..|..              |.::.|
  Rat   360 VAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRLSVLV 424

  Fly   408 PEVSFELLVKRQIRRLEEPSLRCVELIHEEMQR-IVQHCGNEVQQEMLRFPKLHEKIVDVVTQLL 471
            .|...|......:.::.:..|.  :.|.:.|.| :...|.:||...:|   :..::|::.:..||
  Rat   425 DEFCSEFHPTPSVLKVYKSELN--KHIEDGMGRNLADRCTSEVNASIL---QSQQEIIENLKPLL 484

  Fly   472 ----RRRLPHTNVMVENIVAIELAYINTKH---PDFHKD---------AALVPSLLKTDSDPYSQ 520
                :.:| ||.:..:.   .:|:|....|   .||.:|         ::||...|.:.:.....
  Rat   485 PAGIQNKL-HTLIPCKK---FDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVL 545

  Fly   521 INLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENSTPSMASTW 585
            :.|.:.....||                                               |:|||
  Rat   546 LGLSEPIFQVPR-----------------------------------------------SLAST- 562

  Fly   586 LSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLI 650
                 |.||:.|.:.:|:.....:          :.|:..:.:      ||.:......|:..:|
  Rat   563 -----PTAPSNPAAPDNAAQEELM----------ITLITGLAS------LTSRTSMGIIVVGGVI 606

  Fly   651 -----------------KSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQ------SELVTHLYKS 692
                             ..|.|........:..:|.....|||..:.||      |...:|..:.
  Rat   607 WKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQ 671

  Fly   693 DKAETLLNESDHIAVRRKEAADMLKALTR 721
            :.|.|.......:.|.:|...:.:..|::
  Rat   672 EMATTFARLCQQVDVTQKHLEEEIARLSK 700

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.