Protein Alignment Drp1 and dyn-1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_001024332.1
• Gene: dyn-1 / 181644
• WormBaseID: WBGene00001130
• Length: 838
• Species: Caenorhabditis elegans
• Alignment Length: 801
• Identity: 296/801 - (36%)
• Similarity: 428/801 - (53%)
• Gaps: 141/801 - (17%)

  Fly     1 MEALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            |:|||||||::||.|:.:| |.|.:||||.|:|.||:|||||:|:.||:.|||||:||||||||:
 Worm     8 MQALIPVINRVQDAFSQLGTSVSFELPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 72

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||    .||            .|:..|||.| ..|.|||.:|||||:||:|..|.||||.|.|
 Worm    73 LQLI----QDR------------NEYAEFLHKKGHRFVDFDAVRKEIEDETDRVTGQNKGISPHP 121

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||::||.:|:||||:||||:|||||||||.|||.||::::|.:|.....:|||||.||:|:|||
 Worm   122 INLRVFSPNVLNLTLIDLPGLTKVPVGDQPADIEQQIRDMILTFINRETCLILAVTPANSDLATS 186

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||:|||.|.||:.|:|||||||.||||.:||..::..::.|.:||:||.||||:.:|.|.
 Worm   187 DALKLAKEVDPQGLRTIGVLTKLDLMDEGTDAREILENKLFTLRRGYVGVVNRGQKDIVGRKDIR 251

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLP----DLKTRVNIMATQFQSL 317
            ..:..|..|.  ...|..:|.|.||.||..|||:.|.:||||.||    .|:.::..|.......
 Worm   252 AALDAERKFFISHPSYRHMADRLGTSYLQHTLNQQLTNHIRDTLPTLRDSLQKKMFAMEKDVAEY 316

  Fly   318 LNSYGEDVSDKSQTLLQIITKFSSAYCCTIEG-TARNIETTELCGGARMGYIFHETFGRTLDSIH 381
            .|....|...|::.|||::|:|::....:||| :|:.:.|.||.||||:..:|||.|...:..:.
 Worm   317 KNYQPNDPGRKTKALLQMVTQFNADIERSIEGSSAKLVSTNELSGGARINRLFHERFPFEIVKME 381

  Fly   382 PLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCG 446
            ......:.:|..||||..|.|..||.|:::||.:.|:||.||:||||:||:|:..|:..:::.|.
 Worm   382 IDEKEMRKEIQYAIRNIHGIRVGLFTPDMAFEAIAKKQITRLKEPSLKCVDLVVNELANVIRQCA 446

  Fly   447 NEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLL 511
            :    .|.|:|:|.:::..:|...:|.|.......:..||..||||:||.|.||
 Worm   447 D----TMARYPRLRDELERIVVSHMREREQIAKQQIGLIVDYELAYMNTNHEDF----------- 496

  Fly   512 KTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAEN 576
                       :|...|                           :..:||.|.::.:..|.|...
 Worm   497 -----------IGFSNA---------------------------EAKASQGQSAKKNLGNQVIRK 523

  Fly   577 STPSMAS-------------------TWLSN--------ILPPAPTRPDSIEN---STNNT---- 607
            ...|:::                   :|..:        :||....:...||.   |.|:.
 Worm   524 GWLSLSNVSFVRGSKDNWFVLMSDSLSWYKDDEEKEKKYMLPLDGVKLKDIEGGFMSRNHKFALF 588

  Fly   608 -PVHNNIVSPVKPVNL----LPDVPA-------------------NHNPRRLTDKE-----QKDC 643
             |...||....|.:.|    |.::.|                   :.:.:.:.|..     ::..
 Worm   589 YPDGKNIYKDYKQLELGCTNLDEIDAWKASFLRAGVYPEKQKAQEDESQQEMEDTSIDPQLERQV 653

  Fly   644 DVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVR 708
            :.|.:|:.||..|:.|:|:|.||||:||.:||...:.::.||:.|||:....:.|:.||...|.:
 Worm   654 ETIRNLVDSYMRIITKTIKDLVPKAVMHLIVNQTGEFMKDELLAHLYQCGDTDALMEESQIEAQK 718

  Fly   709 RKEAADMLKALTRANHIISEI 729
            |:|...|..|...|..||||:
 Worm   719 REEMLRMYHACKEALRIISEV 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	154/280 (55%)
		Dynamin_M	224..507	CDD:460033	103/289 (36%)
		GED	639..729	CDD:460495	33/94 (35%)
dyn-1	NP_001024332.1	DLP_1	31..296	CDD:206738	154/280 (55%)
		Dynamin_M	217..502	CDD:460033	104/310 (34%)
		PH_dynamin	518..628	CDD:269958	17/109 (16%)
		GED	648..739	CDD:128597	33/90 (37%)