DRSC/TRiP Functional Genomics Resources

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Protein Alignment Drp1 and Mx1

DIOPT Version :10

Sequence 1:NP_608694.2 Gene:Drp1 / 33445 FlyBaseID:FBgn0026479 Length:735 Species:Drosophila melanogaster
Sequence 2:NP_034976.1 Gene:Mx1 / 17857 MGIID:97243 Length:631 Species:Mus musculus


Alignment Length:754 Identity:198/754 - (26%)
Similarity:317/754 - (42%) Gaps:159/754 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |.:.|.|: |.|....:| ...:.||.|.|:|.||||||||:|::.|.: ||||:|||||.||||
Mouse    13 EKVRPCID-LIDTLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVA-LPRGSGIVTRCPLVL 75

  Fly    66 QLIYSPLDDRENRSAENGTSNAEEW-GRFLHTKKCFTDFDEIRKEIE--NETERA--------AG 119
            :|          |..:.|    ||| |:        ..:|:|..|:.  :|.|.|        ||
Mouse    76 KL----------RKLKEG----EEWRGK--------VSYDDIEVELSDPSEVEEAINKGQNFIAG 118

  Fly   120 SNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVT 184
            ...||..:.|:|.:.|.:|.:|||:||||||:|.||:||.||..|||.|:..||:...:|.|.|.
Mouse   119 VGLGISDKLISLDVSSPNVPDLTLIDLPGITRVAVGNQPADIGRQIKRLIKTYIQKQETINLVVV 183

  Fly   185 AANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTD--AIDILCGRVIPVKLGIIGVMNRS 247
            .:|.|:||:|||.:|::|||:|.||:.|:||.||:|.|.:  .:|::...|.|:|.|.:.|..|.
Mouse   184 PSNVDIATTEALSMAQEVDPEGDRTIGVLTKPDLVDRGAEGKVLDVMRNLVYPLKKGYMIVKCRG 248

  Fly   248 QKDIMDQKHIDDQ-MKDEAAFLQRKYPTLATRNG---TPYLAKTLNRLLMHHIRDCLPDLKTRVN 308
            |:||.:|..:.:. .|::..|....|.::...:|   .|.||:.|...|..||...||.|:.::|
Mouse   249 QQDIQEQLSLTEAFQKEQVFFKDHSYFSILLEDGKATVPCLAERLTEELTSHICKSLPLLEDQIN 313

  Fly   309 IMATQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETF 373
            .........|..||.|:.:..:|.:..:....||:...|....:..||... |.:|:.......|
Mouse   314 SSHQSASEELQKYGADIPEDDRTRMSFLVNKISAFNRNIMNLIQAQETVSE-GDSRLFTKLRNEF 377

  Fly   374 GRTLDSIHPLAGLSKMDILTAIR----NATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELI 434
            ....|.|.........::.:.::    ...|.....||...:||.::|::::.|||.::      
Mouse   378 LAWDDHIEEYFKKDSPEVQSKMKEFENQYRGRELPGFVDYKAFESIIKKRVKALEESAV------ 436

  Fly   435 HEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPD 499
                             .|||          .||::                 ::.|::.....|
Mouse   437 -----------------NMLR----------RVTKM-----------------VQTAFVKILSND 457

  Fly   500 FHKDAALVPSLLKTDSDPYSQINLGQRR--ANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQ 562
            |..    ..:|..|......:|.|.|.:  .|..|.|.            |.:|....|....::
Mouse   458 FGD----FLNLCCTAKSKIKEIRLNQEKEAENLIRLHF------------QMEQIVYCQDQVYKE 506

  Fly   563 QYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVP 627
            ....:.|:....|.:         ..::.||              ...||...|.|         
Mouse   507 TLKTIREKEAEKEKT---------KALINPA--------------TFQNNSQFPQK--------- 539

  Fly   628 ANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKS 692
                  .||..|     :.:|| |:|:...|::|...:|..|.:|::....:.::..::..|..:
Mouse   540 ------GLTTTE-----MTQHL-KAYYQECRRNIGRQIPLIIQYFILKTFGEEIEKMMLQLLQDT 592

  Fly   693 DKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRE 731
            .|....|.|......::|.....|..|..|...:::..:
Mouse   593 SKCSWFLEEQSDTREKKKFLKRRLLRLDEARQKLAKFSD 631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Drp1NP_608694.2 DLP_1 23..301 CDD:206738 117/294 (40%)
Dynamin_M 224..507 CDD:460033 58/292 (20%)
GED 639..729 CDD:460495 18/89 (20%)
Mx1NP_034976.1 DLP_1 34..306 CDD:206738 117/294 (40%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 43..50 5/6 (83%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 68..70 1/1 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 144..147 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 213..216 2/2 (100%)
Dynamin_M 225..512 CDD:460033 69/353 (20%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 245..248 0/2 (0%)
Bundle signaling element (BSE). /evidence=ECO:0000250 307..332 6/24 (25%)
Middle domain. /evidence=ECO:0000250 332..499 38/233 (16%)
Stalk. /evidence=ECO:0000250 333..601 62/378 (16%)
Critical for lipid-binding. /evidence=ECO:0000250 520..522 0/10 (0%)
GED 538..629 CDD:128597 21/111 (19%)

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