DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and drp-1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_741403.2	Gene:	drp-1 / 177336	WormBaseID:	WBGene00001093	Length:	712	Species:	Caenorhabditis elegans

Alignment Length:	745	Identity:	446/745 - (59%)
Similarity:	555/745 - (74%)	Gaps:	43/745 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVG--SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPL 63
            ||.||||:|||||||.|:|  .|.||||||||:||||:|||||:|::|||.||||||||||||||
Worm     1 MENLIPVVNKLQDVFATLGRKEDQIQLPQIVVVGSQSAGKSSVLENLVGRDFLPRGTGIVTRRPL 65

  Fly    64 VLQLIYSPLDDRENRSAENGTSNAEEWGRFLHT-KKCFTDFDEIRKEIENETERAAGSNKGICPE 127
            :|||.:..|||...|...|||...::|..|.|| .|.|||||.:|||||:||:|..|.||||...
Worm    66 ILQLNHVALDDESKRRRSNGTLLTDDWAMFEHTGSKVFTDFDAVRKEIEDETDRVTGVNKGISLL 130

  Fly   128 PINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMAT 192
            ||:|||:|..||:|:|||||||||:||||||.:||.||:|::|.||.||:|||||||.||.|.||
Worm   131 PISLKIYSHRVVSLSLVDLPGITKIPVGDQPVNIEEQIREMILLYISNPSSIILAVTPANQDFAT 195

  Fly   193 SEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHI 257
            ||.:|||::||..|:|||||:|||||||.||||:|:|.|:|||||||||||:||||::|:|.|.|
Worm   196 SEPIKLAREVDAGGQRTLAVLTKLDLMDQGTDAMDVLMGKVIPVKLGIIGVVNRSQQNILDNKLI 260

  Fly   258 DDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSYG 322
            .|.:|||.:|:|:||||||:|||||||||.||.|||||||:|||.||.||:||..|.||.|.::|
Worm   261 VDAVKDEQSFMQKKYPTLASRNGTPYLAKRLNMLLMHHIRNCLPALKARVSIMNAQCQSDLVAFG 325

  Fly   323 EDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHPLAGLS 387
            |.|.||::|||||||:|::||..|||||||||||||||||||:.||||:||||:|:|::||..|:
Worm   326 EPVEDKNRTLLQIITRFATAYTSTIEGTARNIETTELCGGARICYIFHDTFGRSLESVNPLENLT 390

  Fly   388 KMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQE 452
            ::|||||||||||||||||||||||||||||||:||||||||||||:||||||:|||||...|||
Worm   391 QLDILTAIRNATGPRPALFVPEVSFELLVKRQIQRLEEPSLRCVELVHEEMQRMVQHCGFTTQQE 455

  Fly   453 MLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDP 517
            |:|||:|::||.:||:.:|:.||..||.:|||:|||||||||||||:| .:|.|| :|||
Worm   456 MIRFPRLYDKINEVVSGVLKERLKPTNELVENLVAIELAYINTKHPEF-TEANLV-TLLK----- 513

  Fly   518 YSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQP-------NSSQQQYSQVHEQNHVAE 575
             .::.|..|...:...|.|   :...|.|...:||..|.|       |:..||..| ..||..|.
Worm   514 -EELLLDDRHGRSRNRHAS---TGERAVSAHGEQQLQPVPGVNGVDLNAVLQQQQQ-QSQNQRAS 573

  Fly   576 NSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQ 640
            |....:    ..|....:.|.|...:::                 |.||:||.....|:||.:||
Worm   574 NGFLGL----FGNAAASSKTSPQEKQSA-----------------NFLPEVPETQLGRKLTSREQ 617

  Fly   641 KDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHI 705
            :|..:||.||::||.||||:||||||||||..|||:|:||||||||..|||.|:.:.||.|::.:
Worm   618 RDVAIIERLIRNYFIIVRKNIQDSVPKAIMALLVNFVRDNLQSELVRQLYKPDEMDDLLAETEDM 682

  Fly   706 AVRRKEAADMLKALTRANHIISEIRETHMW 735
            |.||::..:.:|||.:|:.||||:|||.:|
Worm   683 AQRRRDTLETMKALQQASVIISEVRETQVW 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	191/278 (69%)
		CrfC	88..728	CDD:223771	379/647 (59%)
		Dynamin_M	226..507	CDD:279383	201/280 (72%)
		GED	643..729	CDD:280391	49/85 (58%)
drp-1	NP_741403.2	DLP_1	25..304	CDD:206738	191/278 (69%)
		CrfC	90..705	CDD:223771	379/647 (59%)
		Dynamin_M	229..503	CDD:279383	199/273 (73%)
		GED	618..706	CDD:280391	50/87 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167350
Domainoid	1	1.000	410	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	821	1.000	Inparanoid score	I241
Isobase	1	0.950	-	0	Normalized mean entropy	S470
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		oto19483
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890