Protein Alignment Drp1 and drp-1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_741403.2
• Gene: drp-1 / 177336
• WormBaseID: WBGene00001093
• Length: 712
• Species: Caenorhabditis elegans
• Alignment Length: 745
• Identity: 446/745 - (59%)
• Similarity: 555/745 - (74%)
• Gaps: 43/745 - (5%)

  Fly     1 MEALIPVINKLQDVFNTVG--SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPL 63
            ||.||||:|||||||.|:|  .|.||||||||:||||:|||||:|::|||.||||||||||||||
 Worm     1 MENLIPVVNKLQDVFATLGRKEDQIQLPQIVVVGSQSAGKSSVLENLVGRDFLPRGTGIVTRRPL 65

  Fly    64 VLQLIYSPLDDRENRSAENGTSNAEEWGRFLHT-KKCFTDFDEIRKEIENETERAAGSNKGICPE 127
            :|||.:..|||...|...|||...::|..|.|| .|.|||||.:|||||:||:|..|.||||...
 Worm    66 ILQLNHVALDDESKRRRSNGTLLTDDWAMFEHTGSKVFTDFDAVRKEIEDETDRVTGVNKGISLL 130

  Fly   128 PINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMAT 192
            ||:|||:|..||:|:|||||||||:||||||.:||.||:|::|.||.||:|||||||.||.|.||
 Worm   131 PISLKIYSHRVVSLSLVDLPGITKIPVGDQPVNIEEQIREMILLYISNPSSIILAVTPANQDFAT 195

  Fly   193 SEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHI 257
            ||.:|||::||..|:|||||:|||||||.||||:|:|.|:|||||||||||:||||::|:|.|.|
 Worm   196 SEPIKLAREVDAGGQRTLAVLTKLDLMDQGTDAMDVLMGKVIPVKLGIIGVVNRSQQNILDNKLI 260

  Fly   258 DDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSYG 322
            .|.:|||.:|:|:||||||:|||||||||.||.|||||||:|||.||.||:||..|.||.|.::|
 Worm   261 VDAVKDEQSFMQKKYPTLASRNGTPYLAKRLNMLLMHHIRNCLPALKARVSIMNAQCQSDLVAFG 325

  Fly   323 EDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHPLAGLS 387
            |.|.||::|||||||:|::||..|||||||||||||||||||:.||||:||||:|:|::||..|:
 Worm   326 EPVEDKNRTLLQIITRFATAYTSTIEGTARNIETTELCGGARICYIFHDTFGRSLESVNPLENLT 390

  Fly   388 KMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGNEVQQE 452
            ::|||||||||||||||||||||||||||||||:||||||||||||:||||||:|||||...|||
 Worm   391 QLDILTAIRNATGPRPALFVPEVSFELLVKRQIQRLEEPSLRCVELVHEEMQRMVQHCGFTTQQE 455

  Fly   453 MLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLKTDSDP 517
            |:|||:|::||.:||:.:|:.||..||.:|||:|||||||||||||:| .:|.|| :|||
 Worm   456 MIRFPRLYDKINEVVSGVLKERLKPTNELVENLVAIELAYINTKHPEF-TEANLV-TLLK----- 513

  Fly   518 YSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQP-------NSSQQQYSQVHEQNHVAE 575
             .::.|..|...:...|.|   :...|.|...:||..|.|       |:..||..| ..||..|.
 Worm   514 -EELLLDDRHGRSRNRHAS---TGERAVSAHGEQQLQPVPGVNGVDLNAVLQQQQQ-QSQNQRAS 573

  Fly   576 NSTPSMASTWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQ 640
            |....:    ..|....:.|.|...:::                 |.||:||.....|:||.:||
 Worm   574 NGFLGL----FGNAAASSKTSPQEKQSA-----------------NFLPEVPETQLGRKLTSREQ 617

  Fly   641 KDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHI 705
            :|..:||.||::||.||||:||||||||||..|||:|:||||||||..|||.|:.:.||.|::.:
 Worm   618 RDVAIIERLIRNYFIIVRKNIQDSVPKAIMALLVNFVRDNLQSELVRQLYKPDEMDDLLAETEDM 682

  Fly   706 AVRRKEAADMLKALTRANHIISEIRETHMW 735
            |.||::..:.:|||.:|:.||||:|||.:|
 Worm   683 AQRRRDTLETMKALQQASVIISEVRETQVW 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	191/278 (69%)
		Dynamin_M	224..507	CDD:460033	203/282 (72%)
		GED	639..729	CDD:460495	52/89 (58%)
drp-1	NP_741403.2	DLP_1	25..304	CDD:206738	191/278 (69%)
		Dynamin_M	227..503	CDD:460033	201/275 (73%)
		GED	616..706	CDD:460495	52/89 (58%)