DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and DNM1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001361198.1	Gene:	DNM1 / 1759	HGNCID:	2972	Length:	867	Species:	Homo sapiens

Alignment Length:	804	Identity:	298/804 - (37%)
Similarity:	433/804 - (53%)	Gaps:	133/804 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDS-IQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:.:|.:: :.||||.|:|.||:|||||:|:.|||.|||||:|||||||||
Human     6 MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            |||:             |.|:   |:..|||.| |.||||:|:|.|||.||:|..|:||||.|.|
Human    71 LQLV-------------NATT---EYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.||:|||||||||:|||||||||.|||.||::::::::...|.:||||:.||:|:|.|
Human   120 INLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|:||:.|:|||||||.||||.|:|..:::|::.|.|||:|||||||..:|.|.
Human   185 DALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDIT 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..:..|..|.  ...|..||.|.|||||.|.||:.|.:||||.||.|:.::.......:..:..|
Human   250 AALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.:.|::.|||::.:|:..:...|||:...|:|.||.||||:..||||.|...|..:..
Human   315 KNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:|::::.||.|:||:::..|:...|:.|..
Human   380 DEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKIREPCLKCVDMVISELISTVRQCTK 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
            ::||    :|:|.|::..:||..:|.|...|...|..::.|||||:||.|.||
Human   445 KLQQ----YPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDF------------ 493

  Fly   513 TDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENS 577
                      :|                  .|.:||...|...:..|..|....|..:..:..|:
Human   494 ----------IG------------------FANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINN 530

  Fly   578 TPSMAS--------------TWLSNILPPAPTRPDSIEN-----------------STNNTPVHN 611
            ...|..              :|..:..........|::|                 :..||. ..
Human   531 IGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTE-QR 594

  Fly   612 NIVSPVKPVNLLPD------------VPANHNPRRLTDKE---------------------QKDC 643
            |:....:.:.|..:            :.|...|.|:.|||                     ::..
Human   595 NVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQV 659

  Fly   644 DVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVR 708
            :.|.:|:.||..||.|:::|.:||.|||.::|..|:.:.|||:.:||......||:.||...|.|
Human   660 ETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQR 724

  Fly   709 RKEAADMLKALTRANHIISEIRET 732
            |.|...|..||..|..||.:|..|
Human   725 RDEMLRMYHALKEALSIIGDINTT 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	158/280 (56%)
		CrfC	88..728	CDD:223771	249/710 (35%)
		Dynamin_M	226..507	CDD:279383	105/286 (37%)
		GED	643..729	CDD:280391	34/85 (40%)
DNM1	NP_001361198.1	DYNc	6..245	CDD:197491	148/254 (58%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	64..66		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	216..502	CDD:395818	109/329 (33%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	235..238		1/2 (50%)
		PH_dynamin	520..629	CDD:269958	12/109 (11%)
		GED	657..745	CDD:396682	34/87 (39%)
		PHA03247	<747..852	CDD:223021	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720