Protein Alignment Drp1 and eat-3

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_495986.3
• Gene: eat-3 / 174476
• WormBaseID: WBGene00001134
• Length: 964
• Species: Caenorhabditis elegans
• Alignment Length: 805
• Identity: 174/805 - (21%)
• Similarity: 308/805 - (38%)
• Gaps: 191/805 - (23%)

  Fly     3 ALIPVINKLQDVFNTVGSD---SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTG-IVTRRPL 63
            :||.:.:::.|:.|...|.   |..||::||:|.||:||:||:|.|......|||:| ::||.|:
 Worm   262 SLIDMYSEVLDLLNEYDSSYNTSDNLPRVVVVGDQSAGKTSVLEMVAQARIFPRGSGEMMTRAPV 326

  Fly    64 VLQLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            .:.|...|....:.|.:..         .|..||:  ||..::|.|.|.....:....|.:..|.
 Worm   327 KVTLSEGPYHVAQFRDSSR---------EFDLTKE--TDLQQLRNETEVRMRNSVRDGKTVSNEV 380

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |:|.:...::..:.||||||:......|...:.:..|..:...::||||:|||.:...:.|...|
 Worm   381 ISLTVKGPNLPRMVLVDLPGVISTVTADMARETKDDIIRMSKAHMENPNAIILCIQDGSVDAERS 445

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMD---AGTDAI-DILCGRVIPVK-LGIIGVM----NRSQK 249
            ....|...:||.|:||:.|:||:|:.:   |..|.| .||.|::.|:| ||..||:    |.|..
 Worm   446 NVTDLVSSIDPSGKRTILVLTKVDMAEKNLANPDRIKKILEGKLFPMKALGYFGVVTGRGNSSDS 510

  Fly   250 DIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQF 314
                   ||:..|.|..|..   .:...|:|....::...|.:...:.||              |
 Worm   511 -------IDEIRKYEENFFS---TSQLLRDGVLKPSQMTTRNMSLAVSDC--------------F 551

  Fly   315 QSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARN-------IETTELCGGARMGYIFHET 372
            ..::..     |.:|||......||:      :|...:|       :...||...||
 Worm   552 WRMVRD-----SIESQTDAFRAAKFN------LEAEWKNHFLRIRQLNRDELYDKAR-------- 597

  Fly   373 FGRTLDSIHPLA--GLSKMDILTAIRNATGPRPALF----VPEV------SFELLVKRQIRRLEE 425
             |..||.|..|:  |:.:.:.|...:..:|....:|    :|..      ||...|..:::...:
 Worm   598 -GEILDEIVNLSLIGVEEWEKLLQDKLWSGISSHVFDQILMPAYASSSSGSFNTTVDIKLKHFAD 661

  Fly   426 PSL--RCVELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAI 488
            ..|  :.:|...:.::.:.   ..::.|: .|..|.|:.:.|.:.:                ..|
 Worm   662 KQLAQKSIETGWDTLKEVF---FRQINQD-ARTKKDHDPVFDALKE----------------AVI 706

  Fly   489 ELAYINTKHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQIS-SHSAGSQQPQQQ 552
            |.|.:.....|...|...|           .|:|..:.||...:.......: .|.|.|
 Worm   707 EEAMLTHGWDDKAMDYLRV-----------IQLNAMEDRAVQDKRSWDAACNFLHKAAS------ 754

  Fly   553 QPPQPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTR-----PDSIENSTNNTPVHNN 612
                     ::.:.|.:|  :.::..|..||.||....|.|...     .|.:.:.....|.|..
 Worm   755 ---------ERLAAVKKQ--LTDDRGPGWASKWLMWKTPTADNHYSCVIQDELYSILGADPEHKQ 808

  Fly   613 IVSP---------VKPVNLLPDVPA------------NHNPRRLTDKEQKDCDVIEHLIKSYFYI 656
            .::.         ::...:| :||.            .|...|:.: ..|||       .|.:.:
 Worm   809 ALTDDDITVIRRNIETKGVL-EVPTESIRKQWKLVFKKHFLERIIN-SSKDC-------LSMYQM 864

  Fly   657 VRKSI---QDSVPKAIMHF-----LVNYVKDNLQSELVT--HLYKSDKAETLLNE--------SD 703
            .|:.:   ||...:.|:.|     :||...:.|:.::..  |.....:.:.:|::        ..
 Worm   865 YRQGMIEGQDIDCQTIVLFYRIQKMVNLTCNALRQQITNTEHRRLEKEIKEVLDDWSQEPDIKKK 929

  Fly   704 HIAVRRKEAADMLKALTRANHIISE 728
            ::..||.:.|:.::.:.|....:.|
 Worm   930 YLTGRRVDLAEEIQQVRRIQEKLEE 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	86/287 (30%)
		Dynamin_M	224..507	CDD:460033	61/309 (20%)
		GED	639..729	CDD:460495	19/108 (18%)
eat-3	NP_495986.3	CwlO1	195..>311	CDD:443091	19/48 (40%)
		DLP_1	286..560	CDD:206738	88/313 (28%)
		OPA1_C	616..963	CDD:466080	63/396 (16%)