Protein Alignment Drp1 and fzo-1

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_495161.1
• Gene: fzo-1 / 173990
• WormBaseID: WBGene00001509
• Length: 774
• Species: Caenorhabditis elegans
• Alignment Length: 640
• Identity: 123/640 - (19%)
• Similarity: 213/640 - (33%)
• Gaps: 204/640 - (31%)

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            :||:...|..:.|.|.   .|::   ::|..|..|:|||:.|.:::....||:|.|..|...|.:
 Worm    82 IEAIGDSIKTIMDTFQ---RDNM---KVVFFGRTSNGKSTTINAMLHEKVLPQGMGHTTCCFLQV 140

  Fly    66 -----QLIYSPLDDRENR-------------SAENGTSNAEEWG-----RFLHTKKCFTDFDEIR 107
                 ::.:..|||...:             |.||  |:....|     :..|.||
 Worm   141 EGSEGEVGHLQLDDNPQKIDMKMLGKIGHALSDEN--SDLPAMGQDSLLKVFHPKK--------- 194

  Fly   108 KEIENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPED---IEAQIKELV 169
                        |..|.|      ::....||   ::|.||:...|..|...|   ::|.:..||
 Worm   195 ------------SESGEC------RLLQNDVV---ILDSPGVDLSPEFDSWIDKHCLDADVFVLV 238

  Fly   170 LKYIENPNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVI 234
                .|..|   .:|.|..:.....|.||:|.      ....:..:.|...|.|:.|:
 Worm   239 ----SNAES---TLTQAEKNFFLRVAKKLSKP------NVFILNNRWDASAAETENIE------- 283

  Fly   235 PVKLGIIGVMNRSQKDIMDQKHI--DDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIR 297
            .||.   ..:.|.::.::|:..:  :.::.|...|:..: ..|.:|.....|.:...:...|..|
 Worm   284 DVKK---QHLTRFRQFLVDELEVCSEREVNDRIFFVSSR-EVLESRLKARGLVQKAYQAEGHGTR 344

  Fly   298 DCLPDLKTRVNIMATQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGG 362
                         |.:||:....:...:|..:     |.|||.          |.|....|:.|.
 Worm   345 -------------ALEFQNFERHFEHCISRSA-----IHTKFE----------AHNRRAHEMIGK 381

  Fly   363 ARMGYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQ-------- 419
            .|:          .|:|:...|...:..:...:..:|.......|....||...:.|
 Worm   382 MRL----------NLNSVLTSAAEQRSKLQNNLNESTRTFNECRVNFTQFEKAYREQTEQLRAEV 436

  Fly   420 ------------------IRRLEEP---SLRCVELIHEEMQRIVQHC-GNEVQQE-----MLRFP 457
                              |.|.|:|   |...:....|::...|..| .::::..     |.|..
 Worm   437 HLKVSADFFEEIARLDAIIDRFEQPFDGSSSGMTKYKEDLAIFVDKCLSSDLEARCTGGLMSRIW 501

  Fly   458 KLHEKIVDVVTQLLRRRLPHTNVMVE----------NIVAIELAYINTKHPDFHKDA-------- 504
            .|...:...||::|..  |:.|.:.|          :|.....|.:|    |||:|.
 Worm   502 NLENDMFQYVTKILAE--PYQNKLEEVWRYRAPFKFSICVDVPALVN----DFHEDLEFRFTFGL 560

  Fly   505 -ALVPSLLKTDS-DPYSQINLG---------QRRANTPRNHMSPQISSHSAGSQQ 548
             |::..::...| .|.:.||..         |...|:.|:      :..||.|::
 Worm   561 HAIIRRIIAYRSGQPVTAINTNLLTPLSLKQQSEKNSVRD------AEASAASEE 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	61/305 (20%)
		Dynamin_M	224..507	CDD:460033	58/338 (17%)
		GED	639..729	CDD:460495
fzo-1	NP_495161.1	P-loop containing Nucleoside Triphosphate Hydrolases	<70..>123	CDD:476819	13/46 (28%)
		DLP_2	101..359	CDD:206739	64/329 (19%)
		Fzo_mitofusin	609..767	CDD:461432	0/1 (0%)