DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drp1 and Dnm3

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_017454151.1	Gene:	Dnm3 / 171574	RGDID:	727949	Length:	873	Species:	Rattus norvegicus

Alignment Length:	785	Identity:	297/785 - (37%)
Similarity:	442/785 - (56%)	Gaps:	97/785 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVG-SDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:.:| |..::||||.|:|.||:|||||:|:.|||.|||||:|||||||||
  Rat     6 MEELIPLVNRLQDAFSALGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            |||:               ||.| |:..|||.| |.||||||:|.|||.||:|..|.||||...|
  Rat    71 LQLV---------------TSKA-EYAEFLHCKGKKFTDFDEVRHEIEAETDRVTGMNKGISSVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.||:||||:||||||||||||||.|||.||:::::::|...|.:|||||.||||:|.|
  Rat   120 INLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||:|||.|.||:.|:|||||||.||||.|:|..:::|::.|.:||:|||||||..:|.|.
  Rat   185 DALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYVGVVNRSQKDIDGKKDIK 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVN----IMATQFQSL 317
            ..|..|..|.  ...|..:|.|.|||:|.|.||:.|.:||||.||:.:.::.    .:..:.::.
  Rat   250 AAMLAERKFFLSHPAYRHIADRMGTPHLQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEVEAF 314

  Fly   318 LNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
            .|...||.:.|::.|||::.:|:..:...|||:...::|.||.|||::..||||.|...:..:..
  Rat   315 KNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:||:||.:|:.|||:.|:|:.:|:...|:.|
  Rat   380 NEKELRREISYAIKNIHGIRTGLFTPDMAFEAIVKKQIVKLKGPSLKSVDLVMQELINTVKKC-- 442

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
              .:.:..||:|.|:...:|...:|.|...|...|..::.|:::||||.|.||...|    :..:
  Rat   443 --TKRLANFPRLCEETERIVANHIREREGKTKDQVLLLIDIQVSYINTNHEDFIGFA----NAQQ 501

  Fly   513 TDSDPYSQINLGQRRANTPRNHM----------------------------SPQISSHSAGSQQP 549
            ..|..:.:..:|.:..|.|.:..                            :..:|.:....::.
  Rat   502 RSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSKGYWFVLTAESLSWYKDDEEKE 566

  Fly   550 QQQQPPQPN-----------SSQQQYSQVH-EQNHVAEN--------STPSMASTWLSNILPPAP 594
            ::...|..|           ||:..::..: ||.:|.::        .:.....:|.:::| .|.
  Rat   567 KKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQEDVDSWKASLL-RAG 630

  Fly   595 TRPDSIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIKSYFYIVRK 659
            ..||   .|..:....|:.....:..::.|.:             ::..:.|.:|:.||..|:.|
  Rat   631 VYPD---KSFGSNKTENDENGQAENFSMDPQL-------------ERQVETIRNLVDSYMSIINK 679

  Fly   660 SIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANH 724
            .|:|.:||.|||.::|.|||.:.|||:..||.|:...||:.||...|.||.|...|.:||..|..
  Rat   680 CIRDLIPKTIMHLMINNVKDFINSELLAQLYSSEDQNTLMEESVEQAQRRDEMLRMYQALKEALA 744

  Fly   725 IISEI 729
            ||.:|
  Rat   745 IIGDI 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	161/280 (58%)
		CrfC	88..728	CDD:223771	247/694 (36%)
		Dynamin_M	226..507	CDD:279383	99/286 (35%)
		GED	643..729	CDD:280391	37/85 (44%)
Dnm3	XP_017454151.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720