DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and Dnm1

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_006497725.1	Gene:	Dnm1 / 13429	MGIID:	107384	Length:	914	Species:	Mus musculus

Alignment Length:	756	Identity:	271/756 - (35%)
Similarity:	396/756 - (52%)	Gaps:	132/756 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 RSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIE 111
            |.|||||:||||||||||||:             |.|:   |:..|||.| |.||||:|:|.|||
Mouse   100 RDFLPRGSGIVTRRPLVLQLV-------------NSTT---EYAEFLHCKGKKFTDFEEVRLEIE 148

  Fly   112 NETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENP 176
            .||:|..|:||||.|.||||:::|.||:|||||||||:|||||||||.|||.||::::::::...
Mouse   149 AETDRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKE 213

  Fly   177 NSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGII 241
            |.:||||:.||:|:|.|:|||:||:|||.|:||:.|:|||||||.||||.|:|..:::|::.|.|
Mouse   214 NCLILAVSPANSDLANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYI 278

  Fly   242 GVMNRSQKDIMDQKHIDDQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLK 304
            ||:|||||||..:|.|...:..|..|.  ...|..||.|.|||||.|.||:.|.:||||.||.|:
Mouse   279 GVVNRSQKDIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLR 343

  Fly   305 TRVNIMATQFQSLLNSY----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARM 365
            .::.......:..::.|    .:|.:.|::.|||::.:|:..:...|||:...|:|.||.||||:
Mouse   344 NKLQSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARI 408

  Fly   366 GYIFHETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRC 430
            ..||||.|...|..:.......:.:|..||:|..|.|..||.|:::||..||:|:::|:|||::|
Mouse   409 NRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDLAFEATVKKQVQKLKEPSIKC 473

  Fly   431 VELIHEEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINT 495
            |:::..|:...::.|..::||    :|:|.|::..:||..:|.|...|...|..::.|||||:||
Mouse   474 VDMVVSELTSTIRKCSEKLQQ----YPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNT 534

  Fly   496 KHPDFHKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSS 560
            .|.||                      :|                  .|.:||...|...:..|.
Mouse   535 NHEDF----------------------IG------------------FANAQQRSNQMNKKKTSG 559

  Fly   561 QQQYSQVHEQNHVAENSTPSMAS--------------TWLSNILPPAPTRPDSIEN--------- 602
            .|....|..:..:..|:...|..              :|..:..........|::|
Mouse   560 NQDEILVIRKGWLTINNIGIMKGGSKEYWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKG 624

  Fly   603 --------STNNTPVHNNIVSPVKPVNLLPD------------VPANHNPRRLTDKE-------- 639
                    :..||. ..|:....:.:.|..:            :.|...|.|:.|||
Mouse   625 FMSSKHIFALFNTE-QRNVYKDYRQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEEN 688

  Fly   640 -------------QKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYK 691
                         ::..:.|.:|:.||..||.|:::|.:||.|||.::|..|:.:.|||:.:||.
Mouse   689 GSDSFMHSMDPQLERQVETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYS 753

  Fly   692 SDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRET 732
            .....||:.||...|.||.|...|..||..|..||.:|..|
Mouse   754 CGDQNTLMEESAEQAQRRDEMLRMYHALKEALSIIGDINTT 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	142/255 (56%)
		CrfC	88..728	CDD:223771	249/710 (35%)
		Dynamin_M	226..507	CDD:279383	105/286 (37%)
		GED	643..729	CDD:280391	34/85 (40%)
Dnm1	XP_006497725.1	DLP_1	100..340	CDD:206738	142/255 (56%)
		Dynamin_M	262..548	CDD:366427	109/329 (33%)
		PH_dynamin	566..675	CDD:269958	12/109 (11%)
		GED	702..791	CDD:366984	34/88 (39%)
		PHA03247	<793..910	CDD:223021	1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720