DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and Dnm1l

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_038943816.1	Gene:	Dnm1l / 114114	RGDID:	620416	Length:	761	Species:	Rattus norvegicus

Alignment Length:	784	Identity:	491/784 - (62%)
Similarity:	590/784 - (75%)	Gaps:	72/784 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |||||||||||||||||||:|.||||||||:|:||||||||:||:|||..||||||:||||||:|
  Rat     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLIL 65

  Fly    66 QLIY-SPLDDRENRSAENGT------------------SNAEEWGRFLHTK-KCFTDFDEIRKEI 110
            ||:: ||.|.|:....|||.                  ..|||||:||||| |.:|||||||:||
  Rat    66 QLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEI 130

  Fly   111 ENETERAAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIEN 175
            ||||||.:|:|||:.||||:||:||.:|||||||||||:|||||||||:|||.||:||:|::|.|
  Rat   131 ENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISN 195

  Fly   176 PNSIILAVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGI 240
            ||||||||||||||||||||||::::|||||||||||:||||||||||||:|:|.||||||||||
  Rat   196 PNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGI 260

  Fly   241 IGVMNRSQKDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKT 305
            |||:||||.||.::|.:.|.::||.||||:|||:||.||||.|||:|||||||||||||||:|||
  Rat   261 IGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKT 325

  Fly   306 RVNIMATQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFH 370
            |:|::|.|:|||||||||.|.|||.||||:||||::.||.||||||:.|||:|||||||:.||||
  Rat   326 RINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 390

  Fly   371 ETFGRTLDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIH 435
            |||||||:|:.||.||:.:|||||||||||||||||||||||||||||||:||||||||||||:|
  Rat   391 ETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVH 455

  Fly   436 EEMQRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF 500
            ||||||:|||.|...||:|||||||:.||:|||.|||:|||.||.||.|:|||||||||||||||
  Rat   456 EEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDF 520

  Fly   501 HKDAALVPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQ----QQQPPQPNSSQ 561
            .....|:.:            |:.::|.|.....: |...|....|:.|.    ..|.|.|.:|.
  Rat   521 ADACGLMNN------------NIEEQRRNRLAREL-PSAVSRDKSSKVPSALAPASQEPSPAASA 572

  Fly   562 QQYSQVHEQNHVAENSTPSMAS---------------------TWLSNILPPAPTRPDSIENSTN 605
            :...::.:.|   ...|.::||                     .|...:   ..::.:.:.....
  Rat   573 EADGKLIQDN---RRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGML---KTSKAEELLAEEK 631

  Fly   606 NTPVHNNIVSPVK--PVNLLPDVPANHNP--RRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVP 666
            :.|:.....||.|  .|||| |||.   |  |:|:.:||:||:|||.||||||.||||:||||||
  Rat   632 SKPIPIMPASPQKGHAVNLL-DVPV---PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVP 692

  Fly   667 KAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRE 731
            ||:||||||:|||.||||||..||||...:.||.||:.:|.||||||||||||..|:.||:||||
  Rat   693 KAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRE 757

  Fly   732 THMW 735
            ||:|
  Rat   758 THLW 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	211/297 (71%)
		CrfC	88..728	CDD:223771	419/669 (63%)
		Dynamin_M	226..507	CDD:279383	212/280 (76%)
		GED	643..729	CDD:280391	61/85 (72%)
Dnm1l	XP_038943816.1	DLP_1	23..321	CDD:206738	211/297 (71%)
		Dynamin_M	245..529	CDD:395818	214/283 (76%)
		GED	667..755	CDD:396682	62/87 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I543
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	908	1.000	Inparanoid score	I349
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		oto97773
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980