DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drp1 and DNM1L

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001265393.1	Gene:	DNM1L / 10059	HGNCID:	2973	Length:	749	Species:	Homo sapiens

Alignment Length:	772	Identity:	490/772 - (63%)
Similarity:	589/772 - (76%)	Gaps:	60/772 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSDSIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVL 65
            |||||||||||||||||||:|.||||||||:|:||||||||:||:|||..|||||||||||||:|
Human     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLIL 65

  Fly    66 QLIY-SPLDDRENRSAENGTS------------NAEEWGRFLHTK-KCFTDFDEIRKEIENETER 116
            ||:: |..|.|:....||..:            .|||||:||||| |.:|||||||:||||||||
Human    66 QLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETER 130

  Fly   117 AAGSNKGICPEPINLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIIL 181
            .:|:|||:.||||:|||||.:|||||||||||:|||||||||:|||.||:||:|::|.|||||||
Human   131 ISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIIL 195

  Fly   182 AVTAANTDMATSEALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNR 246
            ||||||||||||||||::::|||||||||||:||||||||||||:|:|.|||||||||||||:||
Human   196 AVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNR 260

  Fly   247 SQKDIMDQKHIDDQMKDEAAFLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMA 311
            ||.||.::|.:.|.::||.||||:|||:||.||||.|||:|||||||||||||||:||||:|::|
Human   261 SQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLA 325

  Fly   312 TQFQSLLNSYGEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRT 376
            .|:|||||||||.|.|||.||||:||||::.||.||||||:.|||:|||||||:.||||||||||
Human   326 AQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRT 390

  Fly   377 LDSIHPLAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRI 441
            |:|:.||.||:.:|||||||||||||||||||||||||||||||:||||||||||||:|||||||
Human   391 LESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRI 455

  Fly   442 VQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAAL 506
            :|||.|...||:|||||||:.||:|||.|||:|||.||.||.|:|||||||||||||||.....|
Human   456 IQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGL 520

  Fly   507 VPSLLKTDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQ----QQQPPQPNSSQQQYSQV 567
            :.:            |:.::|.|.....: |...|....|:.|.    ..|.|.|.:|.:...::
Human   521 MNN------------NIEEQRRNRLAREL-PSAVSRDKSSKVPSALAPASQEPSPAASAEADGKL 572

  Fly   568 HEQNHVAENSTPSMAS---------------TWLSNILPPAPTRPDSIENSTNNTPVHNNIVSPV 617
            .:.   :...|.::||               .|...:   ..::.:.:.....:.|:.....||.
Human   573 IQD---SRRETKNVASGGGGVGDGVQEPTTGNWRGML---KTSKAEELLAEEKSKPIPIMPASPQ 631

  Fly   618 K--PVNLLPDVPANHNP--RRLTDKEQKDCDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVK 678
            |  .|||| |||.   |  |:|:.:||:||:|||.||||||.||||:||||||||:||||||:||
Human   632 KGHAVNLL-DVPV---PVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVK 692

  Fly   679 DNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADMLKALTRANHIISEIRETHMW 735
            |.||||||..||||...:.||.||:.:|.||||||||||||..|:.||:||||||:|
Human   693 DTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	211/291 (73%)
		CrfC	88..728	CDD:223771	419/663 (63%)
		Dynamin_M	226..507	CDD:279383	212/280 (76%)
		GED	643..729	CDD:280391	61/85 (72%)
DNM1L	NP_001265393.1	DLP_1	23..315	CDD:206738	211/291 (73%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	32..39		5/6 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	58..60		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	159..162		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	228..231		2/2 (100%)
		Dynamin_M	239..523	CDD:395818	214/283 (76%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	258..261		1/2 (50%)
		Middle domain. /evidence=ECO:0000269\|PubMed:15208300	357..502		114/144 (79%)
		Interaction with GSK3B. /evidence=ECO:0000269\|PubMed:9731200	461..698		107/259 (41%)
		B domain. /evidence=ECO:0000269\|PubMed:15208300	515..582		13/82 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..603		11/70 (16%)
		GED	655..743	CDD:396682	62/87 (71%)
		Important for homodimerization. /evidence=ECO:0000269\|PubMed:23584531	667..681		11/13 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	437	1.000	Domainoid score	I565
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6384
Inparanoid	1	1.050	915	1.000	Inparanoid score	I361
Isobase	1	0.950	-	0	Normalized mean entropy	S470
OMA	1	1.010	-	-		QHG53558
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	1	1.000	-	-		FOG0002737
OrthoInspector	1	1.000	-	-		oto90663
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2093
SonicParanoid	1	1.000	-	-		X2114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820