DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drp1 and dnm3

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_031757197.1	Gene:	dnm3 / 100489905	XenbaseID:	XB-GENE-1011531	Length:	837	Species:	Xenopus tropicalis

Alignment Length:	793	Identity:	267/793 - (33%)
Similarity:	420/793 - (52%)	Gaps:	143/793 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|:|||.|:.:|.: .:.||||.|:|.||:|||||:|::|||..
Frog     1 MEELIPLVNRLQDAFSAIGQNYQVDLPQIAVVGGQSAGKSSVLENLVGRWI-------------- 51

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTKKC-FTDFDEIRKEIENETERAAGSNKGICPEP 128
                              ...::.|:..|||.|.. :|||.|:|:|||.|||||.|.||||...|
Frog    52 ------------------HVLSSTEYAEFLHCKGTKYTDFSEVRQEIEEETERATGLNKGISAIP 98

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |:|:|:|.||:||:|:||||:|||||||||.|||.||:::::.:|...|.:|||||.||||:|.|
Frog    99 ISLRIYSPHVLNLSLIDLPGVTKVPVGDQPADIETQIRDMIMNFISRENCLILAVTPANTDLANS 163

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :||||||:|||.|.||:.|:|||||||.||:|.:||..:::|::.|.:||:|||||||..:|:|:
Frog   164 DALKLAKEVDPQGLRTIGVITKLDLMDEGTNAQEILENKLLPLRRGYVGVVNRSQKDIDGKKNIN 228

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..::.|..|.  ...|..:|.|.||.:|.|.||:.|.:|||:.||||::::.......|..:..|
Frog   229 AALQAEQMFFLTHPAYRHMADRMGTSHLQKMLNQQLTNHIRETLPDLRSKLQDQLLSLQHEVEVY 293

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.|.|::.||.::..|:..:...|.|:...::|.||.|||::..||||.|        |
Frog   294 KSINPDDPSRKTKALLHMVQHFAVDFEKRIAGSGDQVDTMELSGGAKINRIFHERF--------P 350

  Fly   383 LAGLSKM---------DILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEM 438
            .. |.||         :|..||:|..|.|..||.|:::||.:||:||.:|:.|:|:||:|:.:|:
Frog   351 FE-LVKMVFDEKELRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQIVKLKGPALKCVDLVMQEL 414

  Fly   439 QRIVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDF--- 500
            ...::.|..::.    .:|:|..:...:||..::.....|...|..::.::|:||||.|.||
Frog   415 INTIKKCTTKLS----NYPRLCVETERIVTFHIKESEGKTKDQVLLMIDMQLSYINTNHEDFIGF 475

  Fly   501 ---HKDAALVP--------------------SLLKTDSDPYSQINLGQRRANTPRNHMSPQISSH 542
               .:..:|:.                    |::|..:..|..|...:            .:|.:
Frog   476 VNAQQRCSLLQKKTPIGIQVIRKGWLTISNISIMKGGAKDYWFILTAE------------SLSWY 528

  Fly   543 SAGSQQPQQQQPPQPN-----------SSQQQYSQVH-EQNHVAEN--------STPSMASTWLS 587
            ....::.::...|..|           ||:..::..: ||.:|.::        .:.....:|.:
Frog   529 KDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHIFALFNTEQRNVYKDYRCLELACDSQEEVDSWKA 593

  Fly   588 NILPPAPTRPD-SIENSTNNTPVHNNIVSPVKPVNLLPDVPANHNPRRLTDKEQKDCDVIEHLIK 651
            ::| .|...|| |:.:...||...|..:.|                     :.::..:.|.:|::
Frog   594 SLL-RAGVYPDKSMVDLEENTQSDNFSMDP---------------------QLERQVETIRNLVE 636

  Fly   652 SYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVRRKEAADML 716
            ||..|:.|.|:|.:||.:||.::|.||:.:.|||:..||..:...||:.||...:.:|:|...|.
Frog   637 SYMTIINKGIRDLIPKTLMHLMINSVKEFIHSELLAQLYSYEDQSTLMEESTEQSQKREEKLHMY 701

  Fly   717 KALTRANHIISEI 729
            ..|..|.|||.:|
Frog   702 YCLKEALHIIGDI 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	134/280 (48%)
		CrfC	88..728	CDD:223771	238/702 (34%)
		Dynamin_M	226..507	CDD:279383	96/301 (32%)
		GED	643..729	CDD:280391	32/85 (38%)
dnm3	XP_031757197.1	DYNc	1..224	CDD:197491	128/254 (50%)
		Dynamin_M	195..481	CDD:395818	97/298 (33%)
		PH_dynamin	494..604	CDD:269958	16/122 (13%)
		GED	626..714	CDD:396682	32/87 (37%)
		PHA03247	<717..834	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010