Protein Alignment Drp1 and dnm1b

DIOPT Version :10

• Sequence 1: NP_608694.2
• Gene: Drp1 / 33445
• FlyBaseID: FBgn0026479
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: XP_005165639.1
• Gene: dnm1b / 100333543
• ZFINID: ZDB-GENE-100920-3
• Length: 859
• Species: Danio rerio
• Alignment Length: 802
• Identity: 301/802 - (37%)
• Similarity: 432/802 - (53%)
• Gaps: 134/802 - (16%)

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|::||.|:.:|.: ::.||||.|:|.||:|||||:|:.||:.|||||:|||||||||
Zfish     6 MEDLIPLVNRMQDAFSAIGQNANLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||..|                .|:..|||.| |.||||||:|:|||.||:|..|.||||.|.|
Zfish    71 LQLINCP----------------TEYAEFLHCKGKKFTDFDEVRQEIEAETDRITGQNKGISPVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.:|:|||||||||:|||||||||.||||||::::::::...|.::|||:.||:|:|.|
Zfish   120 INLRVYSPNVLNLTLVDLPGMTKVPVGDQPADIEAQIRDMLMQFVTKENCLLLAVSPANSDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|.||:.|:|||||||.||||.:||..:::|::.|.|||:|||||||..:|.|.
Zfish   185 DALKIAKEVDPQGMRTIGVITKLDLMDEGTDAREILENKLLPLRRGYIGVVNRSQKDIDGKKDIT 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..|..|..|.  ...|..||.|.|||||.|.||:.|.:||||.||.|:.::.......:..:..|
Zfish   250 AAMSAERKFFLTHPSYRHLADRMGTPYLQKALNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.|.|::.|||::.:|:..:...|||:...::|.||.||||:..||||.|...|..:..
Zfish   315 KHFRPDDPSRKTKALLQMVQQFAVDFEKCIEGSGDQVDTVELSGGARINRIFHERFPFELVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:|||||.:::||..:||:|:..|:...|:.|..
Zfish   380 DEKELRKEISYAIKNIHGIRTGLFTPDMAFETIVKRQIAKIKEPCQKCVDLVITELVNTVRQCTK 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
            ::.|    :|.|.|::..:|||.:|.|...|...|..::.|||||:||.|.||
Zfish   445 KLAQ----YPMLREEMERIVTQHIRDRESRTKNQVMLLIDIELAYMNTNHEDF------------ 493

  Fly   513 TDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENS 577
                      :|                  .|.:||...|...:..:..|....|..:..:..|:
Zfish   494 ----------IG------------------FANAQQRSSQMNKKKAAGNQDEIMVIRKGWLTINN 530

  Fly   578 TPSMAS--------------TWLSN--------ILPPAPTRPDSIENS---------TNNTPVHN 611
            ...|..              :|..:        :||....:...||.|         ..||. ..
Zfish   531 IGIMKGGAKEYWFVMTAENLSWYKDDEEKEKKYMLPLDNLKLRDIEKSFMSSKHVFALFNTE-QR 594

  Fly   612 NIVSPVKPVNLLPD------------VPANHNPRRLTDKE----------------------QKD 642
            |:....:.:.|..|            :.|...|.|:||||                      ::.
Zfish   595 NVYKDYRQLELASDTQEEVDSWKASFLRAGVYPERITDKEKQSDTSDESSSDGFMHSMDPQLERQ 659

  Fly   643 CDVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAV 707
            .:.|.:|:.||..||.|:::|.:||.|||.::|..||.:.:||:.:||......||:.||...|.
Zfish   660 VETIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKDFIHAELLANLYSCGDQNTLMEESAEQAQ 724

  Fly   708 RRKEAADMLKALTRANHIISEI 729
            .|:|...|..||..|.:||.:|
Zfish   725 HREEMLRMYHALKEALNIIGDI 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_608694.2	DLP_1	23..301	CDD:206738	158/280 (56%)
		Dynamin_M	224..507	CDD:460033	110/288 (38%)
		GED	639..729	CDD:460495	34/111 (31%)
dnm1b	XP_005165639.1	DYNc	6..245	CDD:197491	146/254 (57%)
		Dynamin_M	215..502	CDD:460033	113/330 (34%)
		PH_dynamin	519..629	CDD:269958	16/110 (15%)
		GED	656..746	CDD:460495	33/89 (37%)
		FAP	797..>855	CDD:429334