DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drp1 and dnm1a

DIOPT Version :9

Sequence 1:	NP_001259946.1	Gene:	Drp1 / 33445	FlyBaseID:	FBgn0026479	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	XP_021331657.1	Gene:	dnm1a / 100307098	ZFINID:	ZDB-GENE-081104-27	Length:	854	Species:	Danio rerio

Alignment Length:	804	Identity:	304/804 - (37%)
Similarity:	433/804 - (53%)	Gaps:	132/804 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEALIPVINKLQDVFNTVGSD-SIQLPQIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLV 64
            ||.|||::|::||.|:.:|.: ::.||||.|:|.||:|||||:|:.||:.|||||:|||||||||
Zfish     6 MEDLIPLVNRMQDAFSAIGQNANLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLV 70

  Fly    65 LQLIYSPLDDRENRSAENGTSNAEEWGRFLHTK-KCFTDFDEIRKEIENETERAAGSNKGICPEP 128
            ||||..|                .|:..|||.| |.||||||:|:|||.||:|..|.||||.|.|
Zfish    71 LQLINCP----------------TEYAEFLHCKGKKFTDFDEVRQEIEAETDRVTGQNKGISPVP 119

  Fly   129 INLKIFSTHVVNLTLVDLPGITKVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATS 193
            |||:::|.:|:|||||||||:|||||||||.|||.|||:::::::...|.::|||:.||:|:|.|
Zfish   120 INLRVYSPNVLNLTLVDLPGMTKVPVGDQPADIEHQIKDMLMQFVTKENCLLLAVSPANSDLANS 184

  Fly   194 EALKLAKDVDPDGRRTLAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHID 258
            :|||:||:|||.|.||:.|:|||||||.||||.|||..:::|::.|.|||:|||||||..:|.|:
Zfish   185 DALKIAKEVDPQGLRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKDIDGKKDIN 249

  Fly   259 DQMKDEAAFL--QRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIMATQFQSLLNSY 321
            ..|..|..|.  ...|..||.|.|||||.||||:.|.:||||.||.|:.::.......:..:..|
Zfish   250 AAMAAERKFFLSHPSYRHLADRMGTPYLQKTLNQQLTNHIRDTLPGLRAKLQSQLLSIEKEVEEY 314

  Fly   322 ----GEDVSDKSQTLLQIITKFSSAYCCTIEGTARNIETTELCGGARMGYIFHETFGRTLDSIHP 382
                .:|.|.|::.|||::.:||..:...|||:...|:|.||.||||:..||||.|...|..:..
Zfish   315 KNFRPDDPSRKTKALLQMVQQFSVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEF 379

  Fly   383 LAGLSKMDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHEEMQRIVQHCGN 447
            .....:.:|..||:|..|.|..||.|:::||.:|||||.:::||..:||:::..|:...|:.|..
Zfish   380 DEKELRKEISYAIKNIHGIRTGLFTPDMAFETIVKRQIGKIKEPCQKCVDMVISELVNTVRQCTK 444

  Fly   448 EVQQEMLRFPKLHEKIVDVVTQLLRRRLPHTNVMVENIVAIELAYINTKHPDFHKDAALVPSLLK 512
            ::.|    :|.|.|::..:|||.:|.|...|...|..::.|||||:||.|.||...|
Zfish   445 KLAQ----YPMLREEMERIVTQHIRDRESRTKNQVLLLIDIELAYMNTNHEDFIGFA-------- 497

  Fly   513 TDSDPYSQINLGQRRANTPRNHMSPQISSHSAGSQQPQQQQPPQPNSSQQQYSQVHEQNHVAENS 577
                     |..||         |.||...:||:|             .|....|..:..:..|:
Zfish   498 ---------NAQQR---------SSQIKKKAAGNQ-------------GQDEIMVIRKGWLTINN 531

  Fly   578 TPSM--------------ASTWLSNILPPAPTRPDSIEN-----------------STNNTPVHN 611
            ...|              :.:|..:...........::|                 :..||. ..
Zfish   532 IGIMKGGAKEYWFVLTAESLSWYKDDEEKEKKYMLQVDNLKFRDVEKGFMSSKHIFALFNTE-QR 595

  Fly   612 NIVSPVKPVNLLPD------------VPANHNPRRLTDKEQKDC--------------------- 643
            |:....:.:.|..:            :.|...|.|:.:||:.|.
Zfish   596 NVYKDYRQLELACESQEEVDGWKASFLRAGVYPERVVEKEKNDAGEENGSDGFMHSMDPQLERQV 660

  Fly   644 DVIEHLIKSYFYIVRKSIQDSVPKAIMHFLVNYVKDNLQSELVTHLYKSDKAETLLNESDHIAVR 708
            :.|.:|:.||..||.|:::|.:||.|||.::|..|:.:.:||:..||......||:.||...|.|
Zfish   661 ETIRNLVDSYMAIVNKTVRDLIPKTIMHLMINNTKEYINAELLASLYSCGDQNTLMEESAEQAQR 725

  Fly   709 RKEAADMLKALTRANHIISEIRET 732
            |.|...|..||..|.:||.:|..|
Zfish   726 RDEMLRMYHALKEALNIIGDISTT 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drp1	NP_001259946.1	DLP_1	23..301	CDD:206738	160/280 (57%)
		CrfC	88..728	CDD:223771	257/710 (36%)
		Dynamin_M	226..507	CDD:279383	112/286 (39%)
		GED	643..729	CDD:280391	33/106 (31%)
dnm1a	XP_021331657.1	DYNc	6..245	CDD:197491	147/254 (58%)
		Dynamin_M	216..501	CDD:307257	114/305 (37%)
		PH_dynamin	520..630	CDD:269958	11/110 (10%)
		GED	658..746	CDD:308047	33/87 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820