DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad1 and RAD1

DIOPT Version :9

Sequence 1:	NP_477440.1	Gene:	Rad1 / 33440	FlyBaseID:	FBgn0026778	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	NP_002844.1	Gene:	RAD1 / 5810	HGNCID:	9806	Length:	282	Species:	Homo sapiens

Alignment Length:	265	Identity:	82/265 - (30%)
Similarity:	153/265 - (57%)	Gaps:	19/265 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VARVEHIKTFIQAIKSICFNDYGMVQVSEDGLRITVEQGKSIQATLFMPPGAFMEFRVQDFQ-CF 78
            ||.:::::.....:|:|.|.::.....:::|:::|||..|.:||..|:..|.|.||:||:.. .|
Human    18 VASLDNVRNLSTILKAIHFREHATCFATKNGIKVTVENAKCVQANAFIQAGIFQEFKVQEESVTF 82

  Fly    79 GVKMNVLSECLSLFGSAD-----CSLRMMYRDKGDPLKIILYPHDDDDVSTECAIKTMDCDEPID 138
            .:.:.||.:|||:|||:.     .:|||.|:..|.||.:.|   ::..|.|.|.|.|.:.:|.:|
Human    83 RINLTVLLDCLSIFGSSPMPGTLTALRMCYQGYGYPLMLFL---EEGGVVTVCKINTQEPEETLD 144

  Fly   139 YD---QNLKDPDLNVIFVRGPNLSKVFNELEKSAEEFEFVTSPNRPHFKITTVGIMQAVFS-VEV 199
            :|   .|:    :|.|.::...|.:.|:||:.::|..:...||::|:|:::|.|  .|..| ::.
Human   145 FDFCSTNV----INKIILQSEGLREAFSELDMTSEVLQITMSPDKPYFRLSTFG--NAGSSHLDY 203

  Fly   200 AKTSPMMMMFNCKQTVVARYKSQQIRMTNKAMQSATKVAIKTNSVGLLELHLVMQGDSQEEIFIQ 264
            .|.|.:|..|:|.||.|.|||...::.:.||:..:.||:|:|::.|.|.|..:::.:..:..|::
Human   204 PKDSDLMEAFHCNQTQVNRYKISLLKPSTKALVLSCKVSIRTDNRGFLSLQYMIRNEDGQICFVE 268

  Fly   265 FFIIP 269
            ::..|
Human   269 YYCCP 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad1	NP_477440.1	PCNA	13..272	CDD:238322	82/265 (31%)
Rad1	NP_477440.1	Rad1	13..253	CDD:280331	80/247 (32%)
RAD1	NP_002844.1	Rad1	17..257	CDD:396631	80/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159570
Domainoid	1	1.000	134	1.000	Domainoid score	I5034
eggNOG	1	0.900	-	-		E1_KOG3194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37695
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4475
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59914
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004120
OrthoInspector	1	1.000	-	-		oto88671
orthoMCL	1	0.900	-	-		OOG6_103936
Panther	1	1.100	-	-	LDO	PTHR10870
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1057
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790