DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and ERG11

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_011871.1	Gene:	ERG11 / 856398	SGDID:	S000001049	Length:	530	Species:	Saccharomyces cerevisiae

Alignment Length:	528	Identity:	107/528 - (20%)
Similarity:	190/528 - (35%)	Gaps:	136/528 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ--KI 95
            ::...||..:..::::|....:.|...|    .|...||..:....|.:   .|.:|:.::  :.
Yeast    22 FLALPLAQRISLIIIIPFIYNIVWQLLY----SLRKDRPPLVFYWIPWV---GSAVVYGMKPYEF 79

  Fly    96 YDKYKGKHRAVGVFV-TRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARL-NPF 158
            :::.:.|:..:..|| ..:...:.|.|: .|| .|.|.:....|.:::         ||.| .|.
Yeast    80 FEECQKKYGDIFSFVLLGRVMTVYLGPK-GHE-FVFNAKLADVSAEAA---------YAHLTTPV 133

  Fly   159 WASGQSW----RRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRY 219
            :..|..:    .|| .:.:..:.|:..::|:..:.   .::.|.:.:...:..|        ||.
Yeast   134 FGKGVIYDCPNSRL-MEQKKFVKGALTKEAFKSYV---PLIAEEVYKYFRDSKN--------FRL 186

  Fly   220 TAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPK 284
            ....         .||:...:.||.                :|:|.|      ||.||......|
Yeast   187 NERT---------TGTIDVMVTQPE----------------MTIFTA------SRSLLGKEMRAK 220

  Fly   285 ETDEF-----------------FSNLTKES------------------IELRLKAGDSTRTDYLS 314
            ...:|                 |.||..|.                  |:.|.|..|....|.:.
Yeast   221 LDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLID 285

  Fly   315 HLLQ---LRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCM-A 375
            .|::   .:|..:.|..::....:.|::.|..||.......|.:|||.|.|||:|..|.:..: .
Yeast   286 SLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG 350

  Fly   376 SEKSLDFEKLSSLQYLEQVIYESLR----LSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMI 436
            .:|.|.::.|..:..|.|.|.|:||    |.||..:..|...:|       :.|..:..|..:::
Yeast   351 GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVP-------NTSYVIPAGYHVLV 408

  Fly   437 -PNYQFHHDKQYFPEPEAFKPERFDNGAYQE------------LMRKGI---FLPFSDGPRICMG 485
             |.|. |...:|||....|...|::..:...            .:.||:   :|||..|...|:|
Yeast   409 SPGYT-HLRDEYFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIG 472

  Fly   486 VPLAMLTL 493
            ...|...|
Yeast   473 EHFAYCQL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	101/491 (21%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	96/460 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1477
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050