DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp309a2 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	521	Identity:	134/521 - (25%)
Similarity:	242/521 - (46%)	Gaps:	84/521 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ 93
            |.::.:|::   :||...::..|:|.|:.|..::|.|:...:||.|.|          |::..:.
Mouse     1 MELIPNLSIQTWVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFG----------NIINYLD 55

  Fly    94 KIY----DKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYAR 154
            .::    |.||...:..|.:...||.:.::|||:...|||.  .||              ..:..
Mouse    56 GMWKFDDDCYKKYGKIWGFYEGPQPILAIMDPEIIKIVLVK--ECY--------------SVFTN 104

  Fly   155 LNPFWASG-----------QSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNN 208
            ..||...|           :.|:||||......:.|:|::.:.|..|.|.:|...:.:: .||..
Mouse   105 RRPFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRRE-EEKEE 168

  Fly   209 ILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQ-PNKVQEMASKWTSYAFYMLTLFMATIVAPC 272
            .:..:|:...|:..|:.....|::..:|..|.:. ..|::::. |:..:..::|::.:...:.|.
Mouse   169 PINMKDIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKIL-KFKFFDPFLLSVVLFPFLTPI 232

  Fly   273 SRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQK-----QATHD-DLV 331
            .. :|....:|:::..||....|:..:.||......|.|:|..::..::.|     :|..| ::.
Mouse   233 YE-MLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMA 296

  Fly   332 GHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIY 396
            ...|..:..|||.:.|::...:|.||.:|.||:||:.||...:.::..:.::.|..::||:.|:.
Mouse   297 AQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNKAPVTYDALMDMEYLDMVVN 361

  Fly   397 ESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAF 454
            |||||            .|.|.|:......|||:       |..:|||.|..|.|.:|:||||.|
Mouse   362 ESLRL------------YPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDF 414

  Fly   455 KPERFDNGAYQELMRKG-----IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLI 514
            .||||..      ..||     |::||.:|||.|:|:..|::::|.|:..:|.||.|....:..|
Mouse   415 CPERFSK------ENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQI 473

  Fly   515 P 515
            |
Mouse   474 P 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	124/480 (26%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	124/483 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820