DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and cyp19a1b

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_021326198.1	Gene:	cyp19a1b / 60640	ZFINID:	ZDB-GENE-001103-4	Length:	513	Species:	Danio rerio

Alignment Length:	521	Identity:	114/521 - (21%)
Similarity:	203/521 - (38%)	Gaps:	119/521 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RGNMYIL-ASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDV 92
            :|.:.:| .:|.|||||.:         :..|.||.:..:.. |...||..| :|:....|...:
Zfish    17 QGTLLLLTGTLMLILLHRI---------FGVKNWRNQSALPG-PGWWLGLGP-VLSYSRFLWMGI 70

  Fly    93 QKIYDKYKGKHRAVGVFVTRQPQILVLDPELA---HEVLVSNFRCYKDSLQSSYLRHAKWDKYAR 154
            ....:.|..|:.::........:.::|..:::   :.||.||          :|.     .::|.
Zfish    71 GTACNYYNEKYGSIARVWINGEETVILSKQVSSAVYHVLKSN----------NYT-----GRFAS 120

  Fly   155 LNPFWASGQ------------SWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKN 207
            .......|.            .|:::||.....::|..|:::..:.              |:..|
Zfish   121 AKGLQCIGMFEQGIIFNSNIAKWKKVRTYFTKALTGPGLQKSVEVC--------------VSATN 171

  Fly   208 NILETRDLCFRYTAHVMADFIWGIDAGTLTR--------------PMEQPN---KVQEMASKWTS 255
            ..|   |:...:|     |....:|...|.|              |:.:..   |:....|.|.:
Zfish   172 RQL---DVLQEFT-----DASGHVDVLNLLRCIVVDVSNRLFLRIPLNEKELLIKIHRYFSTWQT 228

  Fly   256 YAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDST----RTDYLSHL 316
                  .|....|......:..::....||..:....|    :|.:.:|.::|    ..|:.:.|
Zfish   229 ------VLIQPDIFFKLDFVYRKYHLAAKELQDEMGKL----VEQKRQAINNTEKLDEMDFATEL 283

  Fly   317 LQLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASE--KS 379
            :..::..:.:.||:....|.:::...||...:|...|..|.:|.||::::..||.|.:.|.  :|
Zfish   284 IFAQNHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQEIQSQIGSRDVES 348

  Fly   380 LDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLS-ESKSLD---VEVGMTIMIPNYQ 440
            .|.:||:   .||:.|.||||...::         ..::|.| |...:|   |..| |.:|.|..
Zfish   349 ADLQKLN---VLERFIKESLRYHPVV---------DFIMRQSLEDDYIDGYRVAKG-TNLILNIG 400

  Fly   441 FHHDKQYFPEPEAFKPERFDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQ 505
            ..|..::|.:|..|..|.|:|     .:....|.||..|||.|:|..:||:..|:.||.:||.|.
Zfish   401 RMHKTEFFKKPNEFSLENFEN-----TVPSRYFQPFGCGPRACVGKHIAMVMTKAILVTMLSRFT 460

  Fly   506 V 506
            |
Zfish   461 V 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	103/479 (22%)
cyp19a1b	XP_021326198.1	p450	48..482	CDD:306555	103/481 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010