DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	558	Identity:	143/558 - (25%)
Similarity:	228/558 - (40%)	Gaps:	121/558 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASL-ALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLT-LLGTYP---GLLTRKSNL-VF 90
            :|||..| ..:||.||....|..|..:...|.:     .||:. :.|.||   ..|..|:|. .|
Zfish     7 LYILGILFTAVLLLLLASTAYNPLKNYIGKWNE-----MRPIPGMAGAYPIIGNALQFKTNAGDF 66

  Fly    91 DVQKIYDKYKGKHRAVG-VFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYAR 154
            ..|.|....:.:|..:. |:|...|.:::...|.. ||::||.|    .|..||       .|..
Zfish    67 FNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENI-EVVLSNSR----HLDKSY-------SYRF 119

  Fly   155 LNPFW-------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQ-QVAEKNNILE 211
            |:| |       ::|:.||..|.........|.|.....:..:...:|.:.|.: :..|..|...
Zfish   120 LHP-WLGTGLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFN 183

  Fly   212 TRDLC-----------------------FRYTAHVMADFIWGIDAGTLTRPMEQP--------NK 245
            ...||                       :..:.:.|:|.|        |:....|        ||
Zfish   184 FITLCALDIICETAMGKKIYAQSNADSEYVQSVYKMSDII--------TKRQRAPWLWPDWIYNK 240

  Fly   246 VQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRT 310
            ::|  .|..:....:|..|.|.::              :|..||.|:......:    .|:..|.
Zfish   241 LKE--GKEHAKRLKILHSFTANVI--------------RERAEFMSSEPDSDSD----QGERKRQ 285

  Fly   311 DYLSHLLQ--LRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSC 373
            .:|..||:  ..:.::.:|:|:.....|.|.:|:||:..::..||:.:..:|.||:.::.|:...
Zfish   286 AFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEV 350

  Fly   374 M-ASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIP 437
            . :||:.:..|.|..|:|||.||.||||:...:|.:.:     ::..........|..|:..:|.
Zfish   351 FGSSERHVGVEDLKKLRYLECVIKESLRIFPSVPLFAR-----SICEACHINGFKVPKGVNAVII 410

  Fly   438 NYQFHHDKQYFPEPEAFKPERF--DNGAYQELMRKG----IFLPFSDGPRICMGVPLAMLTLKSA 496
            .|..|.|.:||||||.|:||||  :|.       ||    .::|||.|||.|:|...||:..|..
Zfish   411 PYALHRDPRYFPEPEEFQPERFMPENS-------KGRHPYAYIPFSAGPRNCIGQRFAMMEEKVV 468

  Fly   497 LVHILSNFQV--VRGRDRLIPKG------DSGFGVVLQ 526
            |..||.:|.|  .:.|:.|.|.|      :.|..:.||
Zfish   469 LATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQ 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	130/517 (25%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	128/513 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010