DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	512	Identity:	129/512 - (25%)
Similarity:	225/512 - (43%)	Gaps:	71/512 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLV-FDVQ--KIYDK 98
            |:...|:.|::..:::|..|.|:::.|.|:...||...:||   ||:....|. ||::  |.|.|
Zfish     8 SVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRPWPFVGT---LLSYAKGLCNFDMECAKKYGK 69

  Fly    99 YKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPF----- 158
                  ..|::..|.|.::|.|.|:...|||.  .||     |:::...| .......||
Zfish    70 ------VWGIYDGRLPILMVADLEVIKVVLVK--ECY-----SNFINRRK-RTTGLAGPFSDGII 120

  Fly   159 WASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHV 223
            ....:.|:|:|:......:..||::.:.|.........:.|.::..|:.  ::.:::...|:..|
Zfish   121 MVKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQP--VKIKEVVAPYSLDV 183

  Fly   224 MADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFY----MLTLFMATIVAPCSRLLLRFRFYPK 284
            :....:.:|..::..| |.|..:.  ..|:..:..:    :|.|...::..|..:  :....:.|
Zfish   184 ITSSSFSVDIDSINNP-EDPFVIN--VKKFIQFNMFNPLLLLILLFPSLAIPLKK--MGVTLFSK 243

  Fly   285 ETDEFFSNLTKESIELRLKAGDSTRTDYLSHLL-------QLRDQ-------KQATHDDLVGHAL 335
            ...:||.::.|:..:...|..:. |.|:|..:|       |::|.       |..|..:::..:|
Zfish   244 SAMDFFYSVLKKIKDDHNKESEG-RVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSL 307

  Fly   336 TVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLR 400
            ..:|.||:|:.|.|...||.||.||...:||..||......:..:.::.|..:.|||..|.||:|
Zfish   308 VFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMR 372

  Fly   401 LSSLIPQYTKVCTLPTVIRLSES-------KSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPER 458
            |            |||..||..|       ..|.:..|..:.||.|...||...:..|..|:|||
Zfish   373 L------------LPTAPRLERSAKKTVVINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPER 425

  Fly   459 FDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515
            |......|.::.. |:||..|||.|:|:..|::.:|..:|.:|.||.|...::..||
Zfish   426 FSPENKSEFLQYA-FIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIP 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	121/479 (25%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	121/482 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820