DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp309a2 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	514	Identity:	127/514 - (24%)
Similarity:	230/514 - (44%)	Gaps:	65/514 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLAL--ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ- 93
            |..|:||::  ||:.|::..:|:|..|.|.:::|.|:...||....||:  |...|....||::
Zfish     1 MIDLSSLSVTWILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGTF--LSYTKGFFNFDMEC 63

  Fly    94 -KIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYL--RHAKWDKYARL 155
             |.|.|      ..|::..|.|.::|.|.|:...::|.  .||     |::.  |....|....|
Zfish    64 AKKYGK------VWGIYDGRLPILMVTDLEMIKTIMVK--ECY-----STFTNRREINVDLAGPL 115

  Fly   156 NPFWASG------QSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRD 214
                |.|      :.|:|:|.......:..||::.:.|.........:.|  |..:....::.::
Zfish   116 ----ADGITAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNM--QKGDHEQPVKIKE 174

  Fly   215 LCFRYTAHVMADFIWGIDAGTLTRPMEQP--NKVQEMASKWTSYAFYMLTLFMATIVAPCSRLL- 276
            :...|:..|:....:.:|..::..| :.|  ..::... |:..:..::|.|   |:....:.||
Zfish   175 VMASYSLDVVTSSAFSVDIDSINNP-DDPFVTNIKNFL-KFNLFGLFVLLL---TVFPSIANLLG 234

  Fly   277 -LRFRFYPKETDEFFSNLTKESIELRLKAGDST-RTDYLSHLL-------QLRD------QKQAT 326
             :....:.|.|.:||....:   :::.:..||. |.|:...::       |::|      :|..|
Zfish   235 KMGLSMFSKPTVDFFYKALR---KIKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSEQPEKGLT 296

  Fly   327 HDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYL 391
            ..:::..:...::.||:|:.|.|...||.||.||...:||..:|......:..:.::.|..:.||
Zfish   297 DHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPISYDALMKIDYL 361

  Fly   392 EQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKP 456
            |..|.||:||....|:..:||.     :..|...:.:.....|.||.|..:.|.|.:..|..|:|
Zfish   362 EMSINESMRLLPTAPRLERVCK-----KTVEMNGITIPKDTMITIPTYVLNQDPQLWDSPHEFRP 421

  Fly   457 ERFDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515
            |||......|.::.. |:||..|||.|:|:..|::.:|..:|.:|.||.|...::..||
Zfish   422 ERFSPENKSEFLQYA-FMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIP 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	114/474 (24%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910