DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	515	Identity:	134/515 - (26%)
Similarity:	244/515 - (47%)	Gaps:	58/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNL-VFDVQKIYD 97
            :||.||.:|:        :|.:|.|:|::|.|:...:.:...||   :|..|... |||:. .::
Zfish    10 LLAFLAALLV--------IYGSWPHRYFKKLGIPGPKAIPFFGT---MLRYKDGFHVFDMD-CFE 62

  Fly    98 KYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYK--DSLQSSYLRHAKWDKYARLNPFWA 160
            ||   .|..|::..|||.:.::|..:...||:.  .||.  .:.::..|..|.:|..:     .|
Zfish    63 KY---GRIWGIYDGRQPVLCIMDQTIIKTVLIK--ECYSLFTNRRNFRLNGALYDAVS-----IA 117

  Fly   161 SGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMA 225
            ....|||:|:......:..||::.:.|.::...:|.:.| .:.|::....:.::....|:..|:.
Zfish   118 EDDDWRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSM-GKTAKRGESADIKEFFGAYSMDVVT 181

  Fly   226 DFIWGIDAGTLTRPMEQ-PNKVQEMASKWTSYAFYMLTL---FMATIVAPCSRLLLRFRFYPKE- 285
            ...:.:|..:|..|.:. ...:::|.........::|..   |||.::..     :.|..:|..
Zfish   182 STAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEK-----MDFALFPTSV 241

  Fly   286 TDEFFSNL--TKESIELRLKAGDST--RTDYLSHLLQLR-----------DQKQATHDDLVGHAL 335
            ||.|::.|  .|...:.:..|.|:|  |.|:|..::..:           .:|..:..:::..::
Zfish   242 TDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSM 306

  Fly   336 TVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLR 400
            ..:..||:||.:.|....|.||.||...:||:.||.....::..:|:|.|.|:.||:..:.||||
Zfish   307 IFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLR 371

  Fly   401 LSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQ 465
            |..:..:..:||.     :..|...|.:...:.:|:|.|..|.|..|:.|||:||||||..| .:
Zfish   372 LFPVAARLERVCK-----KTVEINGLLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKG-NK 430

  Fly   466 ELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPKGDSGFGVVL 525
            |.:...:::||..|||.|:|:..|.:|:|.|:|.||..|.|....:..:|. :.||..:|
Zfish   431 ESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPL-ELGFNGLL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	123/479 (26%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	123/482 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920