DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	116/479 - (24%)
Similarity:	189/479 - (39%)	Gaps:	133/479 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 GLLTRKSNLVFDVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYL 144
            |||...|          ||: .:||:            :|.|.....:|....:.:.|   |:.:
  Rat   135 GLLVSAS----------DKW-SRHRS------------MLTPAFHFNILKPYVKIFND---STNI 173

  Fly   145 RHAKWDKYARLNPFWASGQSWRRLRTDAQAGISGSRL----RQAYNIWEQGGQMLTEY------M 199
            .||||   .||    |||.|   ...|....||...|    :..::......:..:||      :
  Rat   174 MHAKW---LRL----ASGGS---AHLDMFENISLMTLDTLQKCVFSFNSNCQEKPSEYIAAILEL 228

  Fly   200 TQQVAEKN-NILETRDLCFRYT---------AHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWT 254
            :..|.::| .:|...||.:|.|         .|::.||.:.:              :||
  Rat   229 SALVVKRNEQLLLHMDLLYRLTPDGRRFYKACHLVHDFTYAV--------------IQE------ 273

  Fly   255 SYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQL 319
                                   |.|..||...:       :.|:.:.|   |...|::..||..
  Rat   274 -----------------------RRRTLPKHGGD-------DVIKAKAK---SKTLDFIDVLLLS 305

  Fly   320 RDQ--KQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDF 382
            :|:  |:.:.:|:...|.|.|.:|:||:.:.|...||.||::|..|::.|.|:...:....|.:.
  Rat   306 KDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDSEEI 370

  Fly   383 E---------KLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPN 438
            |         .|:.|.:|...|.|||||...:...::.||..  |.|.:.:.  :..|:..:|..
  Rat   371 ECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQD--ISLPDGRV--IPKGIICIINI 431

  Fly   439 YQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGI-FLPFSDGPRICMGVPLAMLTLKSALVHILS 502
            :..||:...:.:||.:.|.|||....|  .|..: |:|||.|||.|:|...||..:|.|:...|.
  Rat   432 FATHHNPTVWQDPEVYDPFRFDPENIQ--ARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALTLL 494

  Fly   503 NFQVV------RGRDRLIPKGDSG 520
            .|:|:      |.:..||.:.:.|
  Rat   495 RFRVLPDDKEPRRKPELILRAEDG 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	116/479 (24%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	116/479 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010