DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	133/523 - (25%)
Similarity:	238/523 - (45%)	Gaps:	87/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGT----YPGLLTRKSNLV 89
            |.::::|:|   :||.::::..|.:.|..|..::|:|:...:||..|||    |.||..
  Rat     1 MDLVSALSLETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVLNYYRGLWK------ 59

  Fly    90 FDVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYK-------------DSLQS 141
            ||:    :.||...:..|:|..:.|...::|.|:...|||.  .|:.             .|...
  Rat    60 FDM----ECYKKCGKIWGLFDGQTPVFAIMDTEMIKSVLVK--ECFSVFTNRRNIGPVGIMSKSI 118

  Fly   142 SYLRHAKWDKY-ARLNPFWASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAE 205
            |..:..:|.:| |.|:|.:.||                 ||::.:.|.|..|.:|.:|:.|:| |
  Rat   119 SVAKDEEWKRYRAFLSPTFTSG-----------------RLKEMFPIIEHYGDILVKYLKQKV-E 165

  Fly   206 KNNILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVA 270
            |...|..:::...|:..|:....:.::..::..|.:   ...|...|:..:.|:. .||::.::.
  Rat   166 KGKPLAMKEVFGAYSMDVITSTSFEVNINSINNPKD---PFVEKVKKFQRFDFFD-PLFLSVVLF 226

  Fly   271 PCSR---LLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRD-------QKQA 325
            |...   .:|....:||::..||........:.||.:....|.|:|..::...:       .|..
  Rat   227 PFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHKHRVDFLQLMMNAHNNSKDKVSHKAL 291

  Fly   326 THDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQY 390
            :..::|..|:..:...|:|:.:.|...||.||.:|..|:||:.||...:.::....::.:..::|
  Rat   292 SDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNKAPPTYDTVMEMEY 356

  Fly   391 LEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLD---VEVGMTIMIPNYQFHHDKQYFPEPE 452
            |:.|:.|:.||..:..:..:||        .:...||   :..|..:|||.|...||.|::||||
  Rat   357 LDMVLNETPRLYPIGYRLERVC--------KKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPE 413

  Fly   453 AFKPERFDNGAYQELMRKG-----IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDR 512
            .|.||||..      ..||     ::|||.:|||.|:|:..|::.:|.||..:|.||......:.
  Rat   414 EFLPERFSK------ENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEET 472

  Fly   513 LIP 515
            .||
  Rat   473 QIP 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	123/482 (26%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	111/447 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010