DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	522	Identity:	122/522 - (23%)
Similarity:	203/522 - (38%)	Gaps:	101/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GNMYILASLALILLHLLVLPIYLYLTWHHKYWRKRGL----VTARPLTLLGTYPGLLTRKSNLVF 90
            |.:.:::.|.|:||.|.....||     |:.|..:.|    ....|..|.|.     |.|..
Mouse    17 GLLQVVSLLGLLLLLLKSAQYYL-----HRQWLIKSLQQFPPAPPPQWLFGN-----TLKDQ--- 68

  Fly    91 DVQKI---YDKYK--------GKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYL 144
            |:|:|   .:|:.        |.|          .::::.||:....:|..:    ...:..||.
Mouse    69 DLQQILLCVEKFPSTYVRWLWGNH----------ARVVIYDPDYMKVILGRS----DPKVVRSYS 119

  Fly   145 RHAKWDKYARLNPFWASGQSW---RRLRTDA--------QAGISGSRLRQAYNIWEQGGQMLTEY 198
            ..|.|..|..|   ..:|:.|   ||:.|.|        ..||....:....:.||   |::.:.
Mouse   120 FFAPWIGYGLL---LLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVMLDKWE---QLVDQD 178

  Fly   199 MTQQVAEKNNI--LETRDLC-FRYTAHVMAD-------FIWGIDAGT------LTRPMEQPNKVQ 247
            ...::.:..::  :||...| |.|...|..:       :|..::..|      :.....|.|.:.
Mouse   179 CPLEIYQDISLMTMETMMKCAFSYQGSVQLEDCRNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIY 243

  Fly   248 EMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDY 312
            .::|...|  ||    ....|....:..::|.|....:.:.......|:.           |.|:
Mouse   244 SLSSNGRS--FY----HACQIAHKHTERVIRMRKAQLQNEAELEKFRKKK-----------RLDF 291

  Fly   313 LSHLL--QLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMA 375
            |..||  |..|.|..:.:|:.....|.|.:|::|:.:.:....|.||.:|..||:.|.|:.|.:.
Mouse   292 LDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILG 356

  Fly   376 SEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQ 440
            :..|:....|..:.|....|.|:|||...||..::..:.|  :...:..||  ..|..:.:..|.
Mouse   357 NGTSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSP--VTFPDGCSL--PKGFLVTLSFYG 417

  Fly   441 FHHDKQYFPEPEAFKPERFDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQ 505
            .||:.:..|..|.|.|.||..||.::   ...|||||.|.|.|:|....|..||.|:...|..|:
Mouse   418 LHHNPRLRPNAEVFDPSRFAPGAPRQ---THAFLPFSAGTRNCIGKQFTMNELKVAVALTLLRFE 479

  Fly   506 VV 507
            ::
Mouse   480 LL 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	111/478 (23%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	110/475 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010