DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp6a19

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_611001.2	Gene:	Cyp6a19 / 36662	FlyBaseID:	FBgn0033979	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	124/492 - (25%)
Similarity:	224/492 - (45%)	Gaps:	37/492 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ILLHLLVLPIYLYLTW---HHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYDKYKGK 102
            |||.|:|..:.|...|   ::.||::||:....|...||. .|.|.|...|...:::.|.|::.:
  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIPLGN-TGELWRTMPLAGILKRTYLKFRKQ 66

  Fly   103 HRA--VGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSW 165
            ...  .|.::.....|::.|.:....||:.:|    |......:.|.:.|.....|.....||.|
  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDF----DKFHDRGVYHNEKDDPLTNNLATIEGQKW 127

  Fly   166 RRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADFIWG 230
            :.||.......:.::::..::.....|..:...:.::::..:..||..|:..|:|:.|:....:|
  Fly   128 KNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFG 192

  Fly   231 IDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSNLTK 295
            :...:|..|..:..::...|.:...:.:.:..|...   .|...:.|.|:|......:|:..:.:
  Fly   193 LKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFG---MPKLAVKLGFQFLLPSVQKFYMKIVQ 254

  Fly   296 ESIELRLKAGDSTRTDYLSHLLQLRDQ-------KQATHDDLVGHALTVMLDGYDTSGTALLHAL 353
            ::|:.|:|. ..||.|::..|:.::.|       .....:::...|....|.|::...|.:...|
  Fly   255 DTIDYRMKR-KVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTL 318

  Fly   354 YYLAENPAVQQKLRVEILSCMAS-EKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTV 417
            |.||.|..||.|||.||.|.:.. ...|:::.:..|.|:|:||.||||...::....::.|.|
  Fly   319 YELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQDLFYMEKVINESLRKHPVVAHLARIATKP-- 381

  Fly   418 IRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKG---IFLPFSDG 479
            .:.|..|.. :|.|..:::.....|||.:::||||.|.|||||    :|.::|.   .||||..|
  Fly   382 YQHSNPKYF-IEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFD----EEQVKKRPTCAFLPFGAG 441

  Fly   480 PRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPK 516
            ||.|:|:....:.:...|..::.||     |..|.||
  Fly   442 PRNCIGLRFGRMQVIIGLALLIHNF-----RFELHPK 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	113/460 (25%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	113/463 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460998
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900