DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp309a2 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	146/526 - (27%)
Similarity:	243/526 - (46%)	Gaps:	47/526 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYDKYKGKHR 104
            |||:..|:...:|.|..|:.|||:.|:...||..::|...|||..:.:....:.::|:....::.
  Fly     6 LILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNHPDAENE 70

  Fly   105 A-VGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSWRRL 168
            . ||:.|..:|.:|:.|||:...:||.:|..:.:...||   ..|.|.....|.|:....:|:.:
  Fly    71 PFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSS---DPKGDPLGSQNIFFLKNPAWKEV 132

  Fly   169 RTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNI----LETRDLCFRYTAHVMADFIW 229
            |.......:|:||:|.:.:.|:.|..|..::.||......:    ||.::||..||..|:|...:
  Fly   133 RLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATVAY 197

  Fly   230 GIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLL--LRFRFYPKETDEFFSN 292
            |:.|.:.|.|     |.:......:.:.|.:|.....|:|.....|:  :||:..|.|...|...
  Fly   198 GVSANSFTDP-----KCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRFLRK 257

  Fly   293 LTKESIELRLKAGDSTRTDYLSHLLQLR------------DQKQATHDDLVGHALTVMLDGYDTS 345
            .....:..|.|:|.. |.|.:..|::.|            ||.....|.||..|:.....|:::|
  Fly   258 TINYVMSEREKSGQK-RNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESS 321

  Fly   346 GTALLHALYYLAENPAVQQKLRVEILSCMA-SEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYT 409
            .:.:..|:|.||::..|||:||.||...:. |...:..:.:.||::::.::.|.||:...:|...
  Fly   322 SSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPFLD 386

  Fly   410 KVCTLPTVIRLSE-SKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERF--DNGAYQELMRKG 471
            :.||......|:. .|...|..||.:.||.|..|.|.||||:|..|.||||  :|   ::|....
  Fly   387 RECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPEN---RKLHTPY 448

  Fly   472 IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRG-----RDRLIPKGDSGFGVVLQ--GDV 529
            .::||..||..|:|.....|..|..||::|.|..:...     |.:|.||     .::.|  |.:
  Fly   449 TYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPK-----AIITQAKGGI 508

  Fly   530 NLEYRR 535
            :|...|
  Fly   509 HLRLVR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	131/483 (27%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	133/491 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460846
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900