DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp28a5

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_609694.1	Gene:	Cyp28a5 / 34817	FlyBaseID:	FBgn0028940	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	167/500 - (33%)
Similarity:	283/500 - (56%)	Gaps:	20/500 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYDKYKGK 102
            :.|.|:.|:|..:|..|.|::.||||||:...:|..|.|.||.:.|.|.:.::|:..||.:||.|
  Fly     4 ITLTLVSLVVGLLYAVLVWNYDYWRKRGVPGPKPKLLCGNYPNMFTMKRHAIYDLDDIYRQYKNK 68

  Fly   103 HRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSWRR 167
            :.|||:|.:|.||:||::|.||..|.||||:.:.|:..:..: ..|.|.....|||..:|:.|:.
  Fly    69 YDAVGIFGSRSPQLLVINPALARRVFVSNFKNFHDNEIAKNI-DEKTDFIFANNPFSLTGEKWKT 132

  Fly   168 LRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQ--VAEKNNI-LETRDLCFRYTAHVMADFIW 229
            .|.|...|::..|::..|.:..:..|.|||::.:|  :..|:.| .:...|||  |..::.|.:.
  Fly   133 RRADVTPGLTMGRIKTVYPVTNKVCQKLTEWVEKQLRLGSKDGIDAKHMSLCF--TTEMVTDCVL 195

  Fly   230 GIDAGTLT-RPMEQPNKVQEMASK-WTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFSN 292
            |:.|.:.: :|....:|:.::.:: ||...|::||...     |....|::.||.|.:.:.||.:
  Fly   196 GLGAESFSDKPTPIMSKINDLFNQPWTFVLFFILTSSF-----PSLSHLIKLRFVPVDVERFFVD 255

  Fly   293 LTKESIELR---LKAGDS-TRTDYLSHLLQLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHAL 353
            |...::|.|   |.||.. .|:|:|.::|||.:::...:..|:.:::|.:|||::|:.|.|.|.|
  Fly   256 LMGSAVETRRAQLAAGKQFERSDFLDYILQLGEKRNLDNRQLLAYSMTFLLDGFETTATVLAHIL 320

  Fly   354 YYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVI 418
            ..|..|...|..||.||.|.: .:.::.|||||.|.||:..:.|::||........|:||....|
  Fly   321 LNLGRNKEAQNLLREEIRSHL-QDGTIAFEKLSDLPYLDACVQETIRLFPPGFMSNKLCTESIEI 384

  Fly   419 RLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERF-DNGAYQELMRKGIFLPFSDGPRI 482
            ...|..:..||.|.|:::|:|.|..|:::||.|::|:|||| :..|.:....:|:|:.|.||||:
  Fly   385 PNKEGPNFVVEKGTTVVVPHYCFMLDEEFFPNPQSFQPERFLEPDAAKTFRERGVFMGFGDGPRV 449

  Fly   483 CMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPKGDSGFGVVLQG 527
            |:|:..|.:.:|:|:|.::|.|. |:..|:.....|...|.::.|
  Fly   450 CIGMRFATVQIKAAIVELISKFN-VKINDKTRKDNDYEPGQIITG 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	153/465 (33%)
Cyp28a5	NP_609694.1	p450	33..500	CDD:299894	153/470 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472972
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27358
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0007607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910