Protein Alignment Cyp309a2 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 539
• Identity: 145/539 - (26%)
• Similarity: 255/539 - (47%)
• Gaps: 101/539 - (18%)

  Fly    31 NMYILASL-ALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGT----YPGLLTRKSNLVF 90
            |::...|| .|:||.::::.:|.|.|..|..::|:|:...:||..|||    |.|:..      |
Mouse     2 NLFSALSLDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTGIWK------F 60

  Fly    91 DVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQ--------------- 140
            |:: .|:|| ||  ..|:|..:.|.:::.|||....|||      ||.|.
Mouse    61 DME-CYEKY-GK--TWGLFDGQTPLLVITDPETIKNVLV------KDCLSVFTNRREFGPVGIMS 115

  Fly   141 --SSYLRHAKWDKY-ARLNPFWASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQ 202
              .|..:..:|.:| |.|:|.:.||                 ||::.:.:.||.|.:|.:|:.|:
Mouse   116 KAISISKDEEWKRYRALLSPTFTSG-----------------RLKEMFPVIEQYGDILVKYLRQE 163

  Fly   203 VAEKNNILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFY---MLTLF 264
             |||...:..:|:...|:..|:....:|::..:|..| |.|  ..|.|.|:....|:   :.::.
Mouse   164 -AEKGMPVAMKDVLGAYSMDVITSTSFGVNVDSLNNP-EDP--FVEEAKKFLRVDFFDPLLFSVV 224

  Fly   265 MATIVAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRD-------Q 322
            :..::.|... :|....:|.::.|||........|.||.:....|.|:|..::...:       .
Mouse   225 LFPLLTPVYE-MLNICMFPNDSIEFFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNSKDKDSH 288

  Fly   323 KQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSS 387
            |..::.::...::..:..||:|:.:.|...||.||.:|.:|:||:.||...:.::.:...:.:..
Mouse   289 KAFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDTVME 353

  Fly   388 LQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDK 445
            ::||:.|:.|:|||..::.:..:||            ..|||:       |..:|||:|..|||.
Mouse   354 MEYLDMVLNETLRLYPIVTRLERVC------------KKDVELNGVYIPKGSMVMIPSYALHHDP 406

  Fly   446 QYFPEPEAFKPERFDNGAYQELMRKG-----IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQ 505
            |::|:||.|:||||..      ..||     ::|||..|||.|:|:..|::.:|.|:..:|.||.
Mouse   407 QHWPDPEEFQPERFSK------ENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFS 465

  Fly   506 VVRGRDRLIPKGDSGFGVV 524
            ....::..||...|..|::
Mouse   466 FQPCQETQIPLKLSRQGIL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	CYP6-like	101..526	CDD:410679	121/464 (26%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	123/467 (26%)