DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	240/517 - (46%)	Gaps:	79/517 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ILASLALILLHLLVLPIYLYLTWHHK---YWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKI 95
            ||.::..||..:.:        |..:   ||::|.:...:|..|||....:|..:.:....:::.
  Fly     7 ILLAIVTILTGVFI--------WSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRF 63

  Fly    96 Y-DKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKW----DKYARL 155
            | |:.......||:::..||.:|:.|.:|...|||.:|..:.:       |.||.    ||...|
  Fly    64 YFDERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSN-------RFAKCDGRSDKMGAL 121

  Fly   156 NPFWASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGG-------QMLTEYMTQQVAEKNNILETR 213
            :.|.|....||.:||......:|::|:|.:::.|:.|       :.||..:.:..||:..|:..:
  Fly   122 SLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIK 186

  Fly   214 DLCFRYTAHVMADFIWGI----------DAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATI 268
            |:|..|...::|...:|:          :.|:..:.:.:|| |:.:..        :..:|....
  Fly   187 DVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPN-VRRIID--------LFVIFYLPK 242

  Fly   269 VAPCSRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLR-------DQKQAT 326
            :.|    |||.:.:.:...||...:.:..||.|.:.|| .|.|.:..||.|:       |:...|
  Fly   243 LVP----LLRPKLFTEPHAEFLRRVIQLVIEERERGGD-LRNDLIEMLLTLKKEADLQQDKSHFT 302

  Fly   327 H--DDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKS--LDFEKLSS 387
            |  |.|...|.:..:.|.:|...::..|||.||:.|.:|.:||.||....||..:  |.:|.::.
  Fly   303 HHRDFLAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVAR 367

  Fly   388 LQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV------GMTIMIPNYQFHHDKQ 446
            :::|:.|:.|:||...::|...:.|   |.|......||....      ||.:.|.|...|||.:
  Fly   368 MEFLDMVVEETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPK 429

  Fly   447 YFPEPEAFKPERFD--NGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQV 506
            |:|:|:.|.||||.  |.|.|..|.   ::||..|||.|:|:.:.:|.:|..||:.|...:|
  Fly   430 YWPDPDRFDPERFSAANKALQAPMS---YMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRV 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	132/478 (28%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	127/457 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460847
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900