DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	580	Identity:	132/580 - (22%)
Similarity:	230/580 - (39%)	Gaps:	133/580 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PIDQYWTRAKGACSNTKRGNMYILASLALILL----HLLVLPIYLYLTWHHKYWRKRGLVTARPL 72
            |:..|..:..|......|  :|::::|.|::|    .|||....|:..:.         :|.|.|
Mouse     3 PLTDYLLQLLGLEKTAFR--VYVVSALLLLVLFFFFRLLVRAFKLFSDFR---------ITCRKL 56

  Fly    73 TLLGTYPG---LLTRKSNLVFDVQKIYDKYK---GKHRA----VGVFVTRQPQILVLDPELAHEV 127
            :.....||   ||...|..:.:.:.:.::.|   ..|..    ||.|:   |.::::.|:....|
Mouse    57 SCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVLDTMHHIILAWVGPFL---PLLVLVHPDYIKPV 118

  Fly   128 L-VSNFRCYKDSLQSSYL-----------RHAKWDKYAR----------LNPFW--------ASG 162
            | .|.....||....|:|           :..||.::.|          |.|:.        ...
Mouse   119 LGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMH 183

  Fly   163 QSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADF 227
            ..|||...:...        .:::::|....|..:.:.:.|...|:..:.|          |:|:
Mouse   184 AKWRRHLAEGSV--------TSFDMFEHISLMTLDSLQKCVFSYNSDCQER----------MSDY 230

  Fly   228 IWGI---DAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEF 289
            |..|   .|..:.|                .|..:....||..:.|...|.        ::..:.
Mouse   231 ISSIIELSALVVRR----------------QYRLHHYLDFMYYLTADGRRF--------RQACDT 271

  Fly   290 FSNLTKESIELR------------LKAGDSTRTDYLSHLLQLRDQ--KQATHDDLVGHALTVMLD 340
            ..|.|.|.|:.|            |||......|::..||..:|:  |:.:.:|:...|.|.|.:
Mouse   272 VHNFTTEVIQERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDEDIRAEADTFMFE 336

  Fly   341 GYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASE--KSLDFEKLSSLQYLEQVIYESLRLSS 403
            |:||:.:.|..||:.||:.|..|:|.|.||...|...  :.||::.|:.|.:....|.||||...
Mouse   337 GHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLTQLPFTTMCIKESLRQFP 401

  Fly   404 LIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELM 468
            .:...::.||  ..|:|.:.:.  :..|:..::..|..||:...:|:.:.:.|.|||....|:
Mouse   402 PVTLISRRCT--EDIKLPDGRV--IPKGIICLVSIYGTHHNPIVWPDSKVYNPYRFDPDTPQQ-- 460

  Fly   469 RKGI-FLPFSDGPRICMGVPLAMLTLKSALVHILSNFQV-------VRGRDRLIPKGDSG 520
            |..: |:|||.|||.|:|...||..::..:...|..|::       ||.:..||.:.::|
Mouse   461 RSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	119/518 (23%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	115/505 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010