DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4d1

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_476907.2	Gene:	Cyp4d1 / 31188	FlyBaseID:	FBgn0005670	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	126/526 - (23%)
Similarity:	221/526 - (42%)	Gaps:	98/526 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARP----LTL-------LGTYPGLLTRK 85
            |:::  :..||...|.:.:.||   |.|:.|...|::..|    |.|       :|..|..:.:|
  Fly     1 MFLV--IGAILASALFVGLLLY---HLKFKRLIDLISYMPGPPVLPLVGHGHHFIGKPPHEMVKK 60

  Fly    86 SNLVFDVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWD 150
               :|:..:.|    .|.:.:.|::..:..:|:.:|:.. ||::...| :.|          |..
  Fly    61 ---IFEFMETY----SKDQVLKVWLGPELNVLMGNPKDV-EVVLGTLR-FND----------KAG 106

  Fly   151 KYARLNPFW-------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKN- 207
            :|..|.| |       :.|:.|.:.|...........|.|...::|:|.:.|...|.|...:..
  Fly   107 EYKALEP-WLKEGLLVSRGRKWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGD 170

  Fly   208 ---NILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQE--MASKWTS-----------Y 256
               ::.:..:||   |...:.:...|:....      |.|...|  .|.|..|           |
  Fly   171 SGFSLYDWINLC---TMDTICETAMGVSINA------QSNADSEYVQAVKTISMVLHKRMFNILY 226

  Fly   257 AF---YMLTLFMATIVAPCSR-------LLLRF--RFYPKETDEFF-SNLTKESIELRLKAGDST 308
            .|   ||||        |.:|       :|.:|  :...:..:|.. ...::||.......|...
  Fly   227 RFDLTYMLT--------PLARAEKKALNVLHQFTEKIIVQRREELIREGSSQESSNDDADVGAKR 283

  Fly   309 RTDYLSHLLQLR-DQKQATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILS 372
            :..:|..|||.. |::..::.|:.....|.|.:|:||:.:||:...|.:|.:|..|:|...||.|
  Fly   284 KMAFLDILLQSTVDERPLSNLDIREEVDTFMFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRS 348

  Fly   373 CMASEKS--LDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIM 435
            .:.::||  :.:|.|:.|.|::..:.|:||:...:|...:     .|:...|.....:..|..|.
  Fly   349 VVGNDKSTPVSYELLNQLHYVDLCVKETLRMYPSVPLLGR-----KVLEDCEINGKLIPAGTNIG 408

  Fly   436 IPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGIFLPFSDGPRICMGVPLAMLTLKSALVHI 500
            |........::.|.||..|||||||.....|.:....::|||.|||.|:|...|||.:|:.:.::
  Fly   409 ISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNPYAYIPFSAGPRNCIGQKFAMLEIKAIVANV 473

  Fly   501 LSNFQV 506
            |.:::|
  Fly   474 LRHYEV 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	116/488 (24%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	116/487 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010