DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	137/591 - (23%)
Similarity:	228/591 - (38%)	Gaps:	155/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PIDQYWTRAKGACSNTKRGNMYILASLALILL----HLLVLPIYLYLTWHHKYWRKRGLVTARPL 72
            ||..|.....|......|  :|:|::|.|.||    .||:....|:..:.         :|.|.|
  Rat     3 PITDYLLYLLGLEKTAFR--VYVLSALLLFLLFLLFRLLLQAFKLFSDFR---------ITCRRL 56

  Fly    73 TLLGTYPG---LLTRKSNLVFDVQKIYDKYK---GKHRA----VGVFVTRQPQILVLDPELAHEV 127
            :.....||   ||...|..:.:.:.:.::.|   ..|..    ||.|:   |.::::.|:....|
  Rat    57 SCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVLDTMHHIILAWVGPFL---PLLVLVHPDYIKPV 118

  Fly   128 L-VSNFRCYKDSLQSSYL-----------RHAKWDKYAR----------LNPFW-ASGQS----- 164
            | .|.....||....|:|           :..||.::.|          |.|:. ...||
  Rat   119 LGASAAIAPKDEFFYSFLKPWLGDGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQSVNIMH 183

  Fly   165 --WRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQV-------AEK-----NNILETRDL 215
              |||...:...        .:::::|....|..:.:.:.|       .||     ::|:|...|
  Rat   184 AKWRRHLAEGSV--------TSFDMFEHVSLMTLDSLQKCVFSYSSDCQEKLSDYISSIIELSAL 240

  Fly   216 CFR--YTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLR 278
            ..|  |..|...|||:.:.|..                                         .|
  Rat   241 VVRRQYRLHHYLDFIYYLTADG-----------------------------------------RR 264

  Fly   279 FRFYPKETDEFFSNLTKESIELR------------LKAGDSTRTDYLSHLLQLRDQ--KQATHDD 329
            ||    :..:...|.|.|.|:.|            |||......|::..||..:|:  |:.:.:|
  Rat   265 FR----QACDTVHNFTTEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLLLAKDEEGKELSDED 325

  Fly   330 LVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASE--KSLDFEKLSSLQYLE 392
            :...|.|.|.:|:||:.:.|..||:.||:.|..|.|.|.||...|...  :.||::.|:.|.:..
  Rat   326 IRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELEELDWDDLTQLPFTT 390

  Fly   393 QVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPE 457
            ..|.||||....:...::.||  ..|:|.:.:.  :..|:..::..|..|::...:|:.:.:.|.
  Rat   391 MCIKESLRQFPPVTLISRRCT--EDIKLPDGRI--IPKGIICLVSIYGTHYNPLVWPDSKVYNPY 451

  Fly   458 RFDNGAYQELMRKGI-FLPFSDGPRICMGVPLAMLTLKSALVHILSNFQV-------VRGRDRLI 514
            |||....|:  |..: |:|||.|||.|:|...||..::..:...|..|::       ||.:..||
  Rat   452 RFDPDIPQQ--RSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRTRKVRRKPELI 514

  Fly   515 PKGDSG 520
            .:.::|
  Rat   515 LRTENG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	122/529 (23%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	115/501 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010