DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp309a2 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	128/569 - (22%)
Similarity:	220/569 - (38%)	Gaps:	158/569 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLALILLHLLVLPIYLYLTWHH-------KYWR----KRGLVT-----ARPLT-LLGTYP 79
            :.:|...:.:|:.:|......|.|:.|       ..|.    ..|::|     .:.:| |:.|||
  Rat    21 LLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWFLGHLGMITPTEQGLKQVTKLVATYP 85

  Fly    80 -GLLTRKSNLVFDVQKIYDKYKGKHRAVGVFVTRQPQIL--VLDPELAHEVLVSN---FRCYKDS 138
             |.:|....::..:...:........:....|..:..|.  .|.|.|...:|:|:   :.|::..
  Rat    86 QGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCHRRM 150

  Fly   139 L-----------------QSSYLRHAKWDKYARLNPFWASGQSWRRLRTDAQAGISGSRLRQAYN 186
            |                 .|:.:.||||...       |||.|              :||....|
  Rat   151 LTPAFHFNILKPYVKIFNDSTNIMHAKWQDL-------ASGGS--------------ARLDMFKN 194

  Fly   187 IWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMAS 251
            |         ..||         |::...|           ::..|:....:|.|..:.:.|::
  Rat   195 I---------SLMT---------LDSLQKC-----------VFSFDSNCQEKPSEYISAILELS- 229

  Fly   252 KWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFS----------------NLTKESIEL 300
                          |.:.....:|||       .||..:.                |.|...|:.
  Rat   230 --------------ALVAKRYQQLLL-------HTDSLYQLTHNGRRFHKACKLVHNFTDAVIQG 273

  Fly   301 R------------LKAGDSTRT-DYLSHLLQLRDQ--KQATHDDLVGHALTVMLDGYDTSGTALL 350
            |            |||...::| |::..||..:|:  |:.:.:|:...|.|.|.:|:||:.:.|.
  Rat   274 RRRALPSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLS 338

  Fly   351 HALYYLAENPAVQQKLRVEILSCMASEKS--LDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCT 413
            ..||.||.:|..|::.|.|:...:...:|  ::::.|:.|.:|...|.|||||...:...::.||
  Rat   339 WILYNLARHPEYQERCRQEVRELLRDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCT 403

  Fly   414 LPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGI-FLPFS 477
            ...|  |.:.:.  :..|:..:|..:..||:...:|:||.:.|.|||....::  |..: |:|||
  Rat   404 QDIV--LPDGRV--IPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKD--RSPLAFIPFS 462

  Fly   478 DGPRICMGVPLAMLTLKSALVHILSNFQVV------RGRDRLIPKGDSG 520
            .|||.|:|...||..:|.||...|..|:|:      |.:..||.:.:.|
  Rat   463 AGPRNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGG 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	119/515 (23%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	119/516 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010