Protein Alignment Cyp309a2 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 139/552 - (25%)
• Similarity: 221/552 - (40%)
• Gaps: 121/552 - (21%)

  Fly    36 ASLALILLHLLVLPIYLYLTWHHKYWRKRGLVT-ARPLTLLGTYPGLLTRKSNLVFDVQKIYDKY 99
            |||.|.||..:.       ::..|:.:.|.:.| ||...|:|  ..||.:.....|..|.|  :|
Human    27 ASLVLSLLQRVA-------SYARKWQQMRPIPTVARAYPLVG--HALLMKPDGREFFQQII--EY 80

  Fly   100 KGKHR---AVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFW-- 159
            ..::|   .:.::|...|.:.:.:.|....:|.|:.:..|.|:            |..|.| |
Human    81 TEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSM------------YKFLEP-WLG 132

  Fly   160 -----ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQV-AEKNNILETRDLCFR 218
                 ::|..||..|.........:.|....:|..:...:|.:.:.:.: .|..|       ||.
Human   133 LGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFN-------CFF 190

  Fly   219 YTAHVMADFI----WGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRF 279
            |......|.|    .|.:.|.      |.|.    .|::....:.|..:....|..|...|.|.:
Human   191 YITLCALDIICETAMGKNIGA------QSND----DSEYVRAVYRMSEMIFRRIKMPWLWLDLWY 245

  Fly   280 RFYP-----KETDEFFSNLTKESIELR---LKAGDSTRTD-------------YLSHLLQLRDQK 323
            ..:.     |::.:.....|...|..|   :.|.:..|.|             :|..||.:.|.:
Human   246 LMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310

  Fly   324 --QATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMA-SEKSLDFEKL 385
              :.:|:|:.....|.|.:|:||:..|:..:||.|..||.||:|:..|:..... |::....|.|
Human   311 GNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDL 375

  Fly   386 SSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHH 443
            ..|:|||.||.|:|||            .|:|...:.|.|.|.||       |...:|..|..|.
Human   376 KKLRYLECVIKETLRL------------FPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHR 428

  Fly   444 DKQYFPEPEAFKPERF--DNGAYQELMRKG----IFLPFSDGPRICMGVPLAMLTLKSALVHILS 502
            |.:|||.||.|:||||  :|.       :|    .::|||.|||.|:|...|::..|:.|..||.
Human   429 DPRYFPNPEEFQPERFFPENA-------QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR 486

  Fly   503 NFQVVRGRDR--------LIPKGDSGFGVVLQ 526
            :|.:...:.|        ||.:..:|..:.|:
Human   487 HFWIESNQKREELGLEGQLILRPSNGIWIKLK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	CYP6-like	101..526	CDD:410679	119/484 (25%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	122/489 (25%)