DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	129/512 - (25%)
Similarity:	239/512 - (46%)	Gaps:	84/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGT---YPGLLTRKSNLVF 90
            |.|:.:|::   :||...::..|:|.|:.|..::|.|:...:|:.|.||   |...:.:     |
  Rat     1 MEIIPNLSIETWVLLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIFNYGDGMWK-----F 60

  Fly    91 DVQKIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLV-------SNFRCY------KDSLQSS 142
            |    .|.||...:..|.:...||.:.::|||:...|||       :|.||:      |.::..|
  Rat    61 D----DDCYKKYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAITMS 121

  Fly   143 YLRHAKWDKYARLNPFWASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKN 207
                              ..:.|:||||......:..:|::.:.:..|.|..|.:.:.::.| |.
  Rat   122 ------------------EDEEWKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREEA-KG 167

  Fly   208 NILETRDLCFRYTAHVMADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPC 272
            ..:..:|:...|:..|:....:|::..:|..|.:...:..:...|:..:..::|::.:...:.|.
  Rat   168 EPINMKDIFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPI 232

  Fly   273 SRLLLRFRFYPKETDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQK-----QATHD-DLV 331
            .. :|.|..:|:::..||....|...:.||.:...:|.|:|..::..::.|     :|..| ::.
  Rat   233 YE-MLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMA 296

  Fly   332 GHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIY 396
            ..|:..:..|||.:.|::...:|.||..|.||:||:.||...:.::..:.::.|..::||:.|:.
  Rat   297 AQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALMEMEYLDMVVN 361

  Fly   397 ESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAF 454
            |||||            .|...||......|||:       |..:.||.|..|.:.:|:.|||.|
  Rat   362 ESLRL------------YPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEF 414

  Fly   455 KPERFDNGAYQELMRKG-----IFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQV 506
            .||||..      ..||     ::|||.:|||.|:|:..|::::|.|::.:|.||.:
  Rat   415 NPERFSK------ENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNI 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	118/471 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	108/437 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820