DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	147/521 - (28%)
Similarity:	238/521 - (45%)	Gaps:	64/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLT-RKSNLVFDVQKIYDKYKGKH 103
            |:||..|:..:..||.:...||..||:...||..|.|.:..|.: ..|.|   :|:.||.::|..
  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSEL---LQETYDAFRGSA 66

  Fly   104 RAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSWRRL 168
            :..|.:|..:|..:|||.:|...||:.:|..:.|       |.:........|.|...|:.||.|
  Fly    67 KVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVD-------RRSFHGDPLTANLFNLQGEEWRNL 124

  Fly   169 RTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMADFIWGIDA 233
            ||......:..:::..:.......|.|.....:.|..:..:||..||..|||..|:....:|.:.
  Fly   125 RTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELVGSQGAVLELHDLMARYTTDVIGSCAFGTEC 189

  Fly   234 GTLTRPMEQPNKV-------QEMASKWTSYAFYMLTLFMATIVAPCSRLLLRFRFYPKETDEFFS 291
            .:|..|..:..:|       ...:.:|        .:|..|.::..::|.|..|....:..:||:
  Fly   190 SSLREPQAEFRQVGRRIFRNSNRSIRW--------RIFKMTYLSSLAKLGLPVRILHPDITKFFN 246

  Fly   292 NLTKESIELRLKAGDSTRTDYLSHLLQLRDQ---KQATHDDLVGHALTVMLDGYDTSGTALLHAL 353
            .:.:|::||| :..:..|.|::..||.||.|   |..|.:.:...|....:.|::||.:.:.:||
  Fly   247 RIVRETVELR-ERENIRRNDFMDLLLDLRRQENGKGLTMEQMAAQAFVFFVAGFETSSSNMSYAL 310

  Fly   354 YYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVI 418
            :.||:|..||||||:||...:.....|.:|.:..:.||:|.|.|:||         |...|.::.
  Fly   311 FELAKNQDVQQKLRMEINDSIGKHGKLTYEAMMEMPYLDQTITETLR---------KYPALSSLT 366

  Fly   419 RLS----ESKSLD------VEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGIF 473
            ||:    |..|.|      :|.|.::.||....|:|.:.:|||..|:||||...|.:| .....|
  Fly   367 RLASEDYEIPSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRE-RHPTAF 430

  Fly   474 LPFSDGPRICMGVPLAMLTLKSALVHILSNFQV-----------VRGRDRLIPKGDSGFGVVLQG 527
            |.|.||||.|:|:....:.:|..|:.:|..|:.           |..|:.::...|   ||.||.
  Fly   431 LGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSD---GVRLQV 492

  Fly   528 D 528
            |
  Fly   493 D 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	134/487 (28%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	135/491 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.070