Protein Alignment Cyp309a2 and CYP3A5

DIOPT Version :9

• Sequence 1: NP_608689.2
• Gene: Cyp309a2 / 33439
• FlyBaseID: FBgn0041337
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 140/503 - (27%)
• Similarity: 242/503 - (48%)
• Gaps: 49/503 - (9%)

  Fly    32 MYILASLAL---ILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQ 93
            |.::.:||:   :||.:.::.:|||.|..|..:::.|:....||.|||..  |..|:....||.:
Human     1 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV--LSYRQGLWKFDTE 63

  Fly    94 KIYDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPF 158
             .|.|| ||  ..|.:..:.|.:.:.||::...|||.  .||........|....:.|.|   ..
Human    64 -CYKKY-GK--MWGTYEGQLPVLAITDPDVIRTVLVK--ECYSVFTNRRSLGPVGFMKSA---IS 119

  Fly   159 WASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHV 223
            .|..:.|:|:|:......:..:|::.:.|..|.|.:|...:.:: |||...:..:|:...|:..|
Human   120 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE-AEKGKPVTLKDIFGAYSMDV 183

  Fly   224 MADFIWGIDAGTLTRPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLL---LRFRFYPKE 285
            :....:|::..:|..|.:   ...|...|:..:.| :..||::.|:.|....:   |....:||:
Human   184 ITGTSFGVNIDSLNNPQD---PFVESTKKFLKFGF-LDPLFLSIILFPFLTPVFEALNVSLFPKD 244

  Fly   286 TDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQ-----ATHD-DLVGHALTVMLDGYDT 344
            |..|.|.......:.||......|.|:|..::..::.|:     |..| :|...::..:..||:|
Human   245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309

  Fly   345 SGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYT 409
            :.:.|...||.||.:|.|||||:.||.:.:.::....::.:..::||:.|:.|:|||
Human   310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRL-------- 366

  Fly   410 KVCTLPTVIRLSESKSLDVEV-------GMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQEL 467
                .|..|||..:...|||:       |..::||.|..|||.:|:.|||.|:||||..  .::.
Human   367 ----FPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK--KKDS 425

  Fly   468 MRKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515
            :...|:.||..|||.|:|:..|::.:|.||:.:|.||.....::..||
Human   426 IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	129/462 (28%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	129/465 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820