DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	517	Identity:	116/517 - (22%)
Similarity:	202/517 - (39%)	Gaps:	105/517 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVF----DVQKI- 95
            ||:.::::.:|.|...|:        |::.|..|     |.::||   ...:.:|    ::||.
Mouse    17 ASVVILMVTVLKLLSLLF--------RRQKLARA-----LDSFPG---PPKHWLFGHALEIQKTG 65

  Fly    96 -YDKYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLR--HAKWD-KYARLN 156
             .||          .||...|.     ..||.:.:..|..:.:..:..|.:  :::.| |.|.:.
Mouse    66 GLDK----------VVTWTEQF-----PYAHPLWLGQFIVFLNIYEPDYAKAVYSRGDPKAAYVY 115

  Fly   157 PF---W-------ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILE 211
            .|   |       ..|..|.:.|.....|.....|:....|:.:..:::.:...::.:|..:.
Mouse   116 DFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSF-- 178

  Fly   212 TRDLCFRYTAHVMADFIWGI-----DAG-------------TLTRPMEQPNKVQEMASKWTSYAF 258
              |: |....|:..|.:...     |:|             .||..|:|         :..|:.:
Mouse   179 --DI-FCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQ---------RIDSFQY 231

  Fly   259 YMLTLFMATIVAPCSRLLLR-FRFYPKETDEFF----SNLTKESIELRLKAGDSTRTDYLSHLLQ 318
            :...::..|   |..|..|| .:.....||...    :.|..|..:.:|:  :....|:|..||.
Mouse   232 HNDFIYWLT---PHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQ--ERRHLDFLDILLG 291

  Fly   319 LRDQK--QATHDDLVGHALTVMLDGYDTSGTALLHALYYLAENPAVQQKLRVEILSCMASEKSLD 381
            .||:.  :.:..||.....|.|.:|:||:.:.:...||.:|..|..||:.|.|:...:....|..
Mouse   292 ARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQ 356

  Fly   382 FEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQ 446
            ::.|:.:.||...:.|..||...:||..:..:.|  :...:.:||  ..|..|.:..|..|.:..
Mouse   357 WDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKP--VTFVDGRSL--PAGSLISLHIYALHRNSA 417

  Fly   447 YFPEPEAFKPERFDNGAYQELM---RKGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQ 505
            .:|:||.|.|.||.    .|.|   ....|:|||.|||.|:|...||..:|......|..|:
Mouse   418 VWPDPEVFDPLRFS----PENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFE 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	108/483 (22%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	107/474 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010