DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp309a2 and Cyp3a13

DIOPT Version :9

Sequence 1:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_031845.1	Gene:	Cyp3a13 / 13113	MGIID:	88610	Length:	503	Species:	Mus musculus

Alignment Length:	494	Identity:	140/494 - (28%)
Similarity:	245/494 - (49%)	Gaps:	42/494 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YILASLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYD 97
            ::|.:.:|:||       |||.|..|..::|.|:...:||..|||.  |..:|.....|:| .:.
Mouse    12 WMLLATSLVLL-------YLYGTHSHGIFKKLGIPGPKPLPFLGTI--LAYQKGFWECDIQ-CHK 66

  Fly    98 KYKGKHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNP--FWA 160
            || ||  ..|::..|||.:.:.||::...|||.  .||     |::....::.....|..  ..:
Mouse    67 KY-GK--MWGLYDGRQPVLAITDPDIIKTVLVK--ECY-----STFTNRRRFGPVGILKKAISIS 121

  Fly   161 SGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKNNILETRDLCFRYTAHVMA 225
            ..:.|:|:|.......:..||::.:.|..|...:|...|.|.:.| ......:|:...|:..|:.
Mouse   122 ENEEWKRIRALLSPTFTSGRLKEMFPIINQFTDVLVRNMRQGLGE-GKPTSMKDIFGAYSMDVIT 185

  Fly   226 DFIWGIDAGTLTRPMEQ-PNKVQEMASKWTSY--AFYMLTLFMATIVAPCSRLLLRFRFYPKETD 287
            ...:|::..:|..|.:. ..|::::. |:..:  .|..:|||  ..:.|... .|....:|::..
Mouse   186 ATSFGVNIDSLNNPQDPFVEKIKKLL-KFDIFDPLFLSVTLF--PFLTPVFD-ALNVSLFPRDVI 246

  Fly   288 EFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQK-----QATHD-DLVGHALTVMLDGYDTSG 346
            .||:...:...|.|:|..:..|.|:|..::..::.|     :|..| ::|..::..:..||:|:.
Mouse   247 SFFTTSVERMKENRMKEKEKQRVDFLQLMINSQNYKTKESHKALSDVEIVAQSVIFIFAGYETTS 311

  Fly   347 TALLHALYYLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKV 411
            :||..|||.||.:|.||:||:.||.:.:.::....::.|..::||:.|:.|:|||..:..:..:|
Mouse   312 SALSFALYLLAIHPDVQKKLQDEIDAALPNKAPATYDTLLQMEYLDMVVNETLRLYPIAGRLERV 376

  Fly   412 CTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMRKGIFLPF 476
            |....     |...|.:..|..:|||.:..|.|.:|:||||.|:||||.. ..|:.:...::|||
Mouse   377 CKTDV-----EINGLFIPKGTVVMIPTFALHKDPKYWPEPEEFRPERFSK-KNQDSINPYMYLPF 435

  Fly   477 SDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIP 515
            ..|||.|:|:..|::.:|.|||.:|.||.|...::..||
Mouse   436 GSGPRNCIGMRFALINMKVALVRVLQNFTVQPCKETEIP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	129/457 (28%)
Cyp3a13	NP_031845.1	p450	39..491	CDD:365848	129/460 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810